Direct and consensual murine pupillary reflex metrics: Establishing normative values

Rehana Z. Hussain, Steven C. Hopkins, Elliot M. Frohman, Todd N. Eagar, Petra C. Cravens, Benjamin M. Greenberg, Steven Vernino, Olaf Stüve

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Pupillometry is a non-invasive technique, based on well-established neurophysiologic principles, that can be utilized to objectively characterize pathophysiologic demyelinating and neurodegenerative changes involving the pupillary reflex pathway. In animal models of human disorders, pupillometry derived reflex metrics could potentially be used to longitudinally monitor disease activity and responses to pharmacotherapies. These investigations would have important implications for translational initiatives focused on the identification and application of novel neuroprotective and restorative treatments for human diseases such as multiple sclerosis. Here, we have established normal reference values for various pupillary reflex metrics across different mouse strains. Ultimately, we anticipate that this new data will help to catalyze unique lines of inquiry using pupillometry methods.

Original languageEnglish (US)
Pages (from-to)164-167
Number of pages4
JournalAutonomic Neuroscience: Basic and Clinical
Volume151
Issue number2
DOIs
StatePublished - Dec 3 2009

Keywords

  • Experimental autoimmune encephalomyelitis
  • Mouse models
  • Multiple sclerosis
  • Pupillometry

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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