Direct Electrophilic Silylation of Terminal Alkynes

Aleksey A. Andreev, Valeri V. Konshin, Nikolai V. Komarov, Michael Rubin, Chad Brouwer, Vladimir Gevorgyan

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27 Scopus citations

Abstract

(Equation presented) A variety of alkynylsilanes were efficiently prepared via direct silylation of terminal alkynes with aminosilanes in the presence of zinc halides. Base- and nucleophile-sensitive functionalities were perfectly tolerated under the above reaction conditions. Initial mechanistic studies support the electrophilic character of this transformation.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalOrganic Letters
Volume6
Issue number3
DOIs
Publication statusPublished - Feb 5 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Andreev, A. A., Konshin, V. V., Komarov, N. V., Rubin, M., Brouwer, C., & Gevorgyan, V. (2004). Direct Electrophilic Silylation of Terminal Alkynes. Organic Letters, 6(3), 421-424. https://doi.org/10.1021/ol036328p