Direct palladium-catalyzed alkynylation of N-fused heterocycles

Ilya V. Seregin, Victoria Ryabova, Vladimir Gevorgyan

Research output: Contribution to journalArticle

221 Scopus citations

Abstract

The first example of direct C-H alkynylation of electron-rich heteroaromatics has been demonstrated. This mild, simple, and general method allows for the efficient synthesis of diverse alkynyl heterocycles. Kinetic isotope effect studies support an electrophilic substitution pathway for this transformation.

Original languageEnglish (US)
Pages (from-to)7742-7743
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number25
DOIs
Publication statusPublished - Jun 27 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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