Abstract
Directing sugar traffic. Golgi-resident glycosyltransferases act in concert to direct synthesis of a wide variety of cell-surface glycans. A re-engineered fucosyltransferase, whose activity is controlled with the small molecule rapamycin, can be used to divert flux away from production of one glycan (αGal) and toward synthesis of another (H antigen).
Original language | English (US) |
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Pages (from-to) | 1455-1458 |
Number of pages | 4 |
Journal | ChemBioChem |
Volume | 5 |
Issue number | 10 |
DOIs | |
State | Published - Oct 4 2004 |
Keywords
- Carbohydrates
- Cell surface
- Chemical genetics
- Glycosylation
- Protein engineering
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry