Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7- oxo-7,8-dihydro-pyrido[2,3- d ]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5)

M. V.Ramana Reddy, Balireddy Akula, Stephen C. Cosenza, Saikrishna Athuluridivakar, Muralidhar R. Mallireddigari, Venkat R. Pallela, Vinay K. Billa, D. R.C.Venkata Subbaiah, E. Vijaya Bharathi, Rodrigo Vasquez-Del Carpio, Amol Padgaonkar, Stacey J. Baker, E. Premkumar Reddy