Discovery of small-molecule inhibitors of tyrosinase

Juris P. Germanas, Shugauang Wang, Andrew Miner, Wayne Hao, Joseph M. Ready

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

To identify novel inhibitors of tyrosinase, a fluorescent assay was developed which is suitable for high-throughput screening. In the assay, oxidation of the substrate by tyrosinase leads to the release of a fluorescent coumarin. Several small molecules were identified that inhibited mushroom tyrosinase in vitro and human tyrosinase in cell culture. These compounds may represent lead structures for therapies targeted at disorders of hyperpigmentation.

Original languageEnglish (US)
Pages (from-to)6871-6875
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number24
DOIs
StatePublished - Dec 15 2007

Keywords

  • Fluorescence
  • High-throughput screening
  • Pigmentation
  • Thiazoles
  • Tyrosinase inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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