Studies to elucidate the mechanism responsible for tetracycline toxicity in pregnant women during an episode of acute pyelonephritis are reported. The rate at which tetracycline disappears from blood, the quantity excreted in urine, endogenous creatinine clearance, and liver function have been determined. From these and previous studies, it would appear that renal function impairment, which occurs during the course of acute pyelonephritis in pregnancy, is an important factor in the genesis of tetracycline toxicity.
|Original language||English (US)|
|Number of pages||6|
|Journal||Obstetrics and gynecology|
|State||Published - Dec 1970|
ASJC Scopus subject areas
- Obstetrics and Gynecology