Disruption of neutrophil extracellular traps (Nets) links mechanical strain to post-traumatic inflammation

Shailesh Agarwal; Shawn J. Loder; David Cholok; John Li; Guowu Bian; Srilakshmi Yalavarthi; Shuli Li; William F. Carson; Charles Hwang; Simone Marini; Chase Pagani; Nicole Edwards; Matthew J. Delano; Theodore J. Standiford; Jason S. Knight; Steven L. Kunkel; Yuji Mishina; Peter A. Ward; Benjamin Levi

doi:10.3389/fimmu.2019.02148

Disruption of neutrophil extracellular traps (Nets) links mechanical strain to post-traumatic inflammation

Shailesh Agarwal, Shawn J. Loder, David Cholok, John Li, Guowu Bian, Srilakshmi Yalavarthi, Shuli Li, William F. Carson, Charles Hwang, Simone Marini, Chase Pagani, Nicole Edwards, Matthew J. Delano, Theodore J. Standiford, Jason S. Knight, Steven L. Kunkel, Yuji Mishina, Peter A. Ward, Benjamin Levi

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated with impaired wound healing and increased inflammation. The exact mechanisms behind this are not fully elucidated. Neutrophil extracellular traps (NETs), a component of the neutrophil response to trauma, are implicated in a range of pro-inflammatory conditions. In the current study, we evaluated their role in linking movement and inflammation. We found that a link exists between the disruption and amplification of NETs which harbors the potential to regulate the wound’s response to mechanical strain, while leaving the initial inflammatory signal necessary for physiologic wound healing intact.

Original language	English (US)
Article number	2148
Journal	Frontiers in immunology
Volume	10
Issue number	OCT
DOIs	https://doi.org/10.3389/fimmu.2019.02148
State	Published - 2019
Externally published	Yes

Keywords

Inflammation
Movement
NET
Neutrophils
Trauma

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2019.02148

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Agarwal, S., Loder, S. J., Cholok, D., Li, J., Bian, G., Yalavarthi, S., Li, S., Carson, W. F., Hwang, C., Marini, S., Pagani, C., Edwards, N., Delano, M. J., Standiford, T. J., Knight, J. S., Kunkel, S. L., Mishina, Y., Ward, P. A., & Levi, B. (2019). Disruption of neutrophil extracellular traps (Nets) links mechanical strain to post-traumatic inflammation. Frontiers in immunology, 10(OCT), Article 2148. https://doi.org/10.3389/fimmu.2019.02148

Agarwal, S, Loder, SJ, Cholok, D, Li, J, Bian, G, Yalavarthi, S, Li, S, Carson, WF, Hwang, C, Marini, S, Pagani, C, Edwards, N, Delano, MJ, Standiford, TJ, Knight, JS, Kunkel, SL, Mishina, Y, Ward, PA & Levi, B 2019, 'Disruption of neutrophil extracellular traps (Nets) links mechanical strain to post-traumatic inflammation', Frontiers in immunology, vol. 10, no. OCT, 2148. https://doi.org/10.3389/fimmu.2019.02148

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abstract = "Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated with impaired wound healing and increased inflammation. The exact mechanisms behind this are not fully elucidated. Neutrophil extracellular traps (NETs), a component of the neutrophil response to trauma, are implicated in a range of pro-inflammatory conditions. In the current study, we evaluated their role in linking movement and inflammation. We found that a link exists between the disruption and amplification of NETs which harbors the potential to regulate the wound{\textquoteright}s response to mechanical strain, while leaving the initial inflammatory signal necessary for physiologic wound healing intact.",

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author = "Shailesh Agarwal and Loder, {Shawn J.} and David Cholok and John Li and Guowu Bian and Srilakshmi Yalavarthi and Shuli Li and Carson, {William F.} and Charles Hwang and Simone Marini and Chase Pagani and Nicole Edwards and Delano, {Matthew J.} and Standiford, {Theodore J.} and Knight, {Jason S.} and Kunkel, {Steven L.} and Yuji Mishina and Ward, {Peter A.} and Benjamin Levi",

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AU - Li, John

AU - Bian, Guowu

AU - Yalavarthi, Srilakshmi

AU - Li, Shuli

AU - Carson, William F.

AU - Hwang, Charles

AU - Marini, Simone

AU - Pagani, Chase

AU - Edwards, Nicole

AU - Delano, Matthew J.

AU - Standiford, Theodore J.

AU - Knight, Jason S.

AU - Kunkel, Steven L.

AU - Mishina, Yuji

AU - Ward, Peter A.

AU - Levi, Benjamin

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AB - Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated with impaired wound healing and increased inflammation. The exact mechanisms behind this are not fully elucidated. Neutrophil extracellular traps (NETs), a component of the neutrophil response to trauma, are implicated in a range of pro-inflammatory conditions. In the current study, we evaluated their role in linking movement and inflammation. We found that a link exists between the disruption and amplification of NETs which harbors the potential to regulate the wound’s response to mechanical strain, while leaving the initial inflammatory signal necessary for physiologic wound healing intact.

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KW - Movement

KW - NET

KW - Neutrophils

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Disruption of neutrophil extracellular traps (Nets) links mechanical strain to post-traumatic inflammation

Abstract

Keywords

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