@article{31caee4c8d6f415994aa7e6b8fb2e3bc,
title = "Disruption of neutrophil extracellular traps (Nets) links mechanical strain to post-traumatic inflammation",
abstract = "Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is associated with impaired wound healing and increased inflammation. The exact mechanisms behind this are not fully elucidated. Neutrophil extracellular traps (NETs), a component of the neutrophil response to trauma, are implicated in a range of pro-inflammatory conditions. In the current study, we evaluated their role in linking movement and inflammation. We found that a link exists between the disruption and amplification of NETs which harbors the potential to regulate the wound{\textquoteright}s response to mechanical strain, while leaving the initial inflammatory signal necessary for physiologic wound healing intact.",
keywords = "Inflammation, Movement, NET, Neutrophils, Trauma",
author = "Shailesh Agarwal and Loder, {Shawn J.} and David Cholok and John Li and Guowu Bian and Srilakshmi Yalavarthi and Shuli Li and Carson, {William F.} and Charles Hwang and Simone Marini and Chase Pagani and Nicole Edwards and Delano, {Matthew J.} and Standiford, {Theodore J.} and Knight, {Jason S.} and Kunkel, {Steven L.} and Yuji Mishina and Ward, {Peter A.} and Benjamin Levi",
note = "Funding Information: SA funded by NIH F32 AR066499, NIH Loan Repayment Program; SJL funded by Howard Hughes Medical Institute (HHMI) Medical Fellows Program; BL funded by NIH, NIGMS K08GM109105, NIH R01GM123069, ACS Clowes Award, International Fibrodysplasia Ossificans Progressiva Association Research Award. JK funded by NIH R01HL134846. YM funded by NIH R01DE020843, DoD W81XWH-11-2-0073. Publisher Copyright: {\textcopyright} 2019 Agarwal, Loder, Cholok, Li, Bian, Yalavarthi, Li, Carson, Hwang, Marini, Pagani, Edwards, Delano, Standiford, Knight, Kunkel, Mishina, Ward and Levi.",
year = "2019",
doi = "10.3389/fimmu.2019.02148",
language = "English (US)",
volume = "10",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",
number = "OCT",
}