Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease

K. Orth, Z. Xu, M. B. Mudgett, Z. Q. Bao, L. E. Palmer, J. B. Bliska, W. F. Mangel, B. Staskawicz, J. E. Dixon

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Abstract

Homologs of the Yersinia virulence effector YopJ are found in both plant and animal bacterial pathogens, as well as plant symbionts. These YopJ family members were shown to act as cysteine proteases. The catalytic triad of the protease was required for inhibition of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) signaling in animal cells and for induction of LocaLized ceLL death in plants. The substrates for YopJ were shown to be highly conserved ubiquitin-Like moLecuLes, which are covalently added to numerous regulatory proteins. YopJ family members exert their pathogenic effect on ceLLs by disrupting this posttranslational modification.

Original languageEnglish (US)
Pages (from-to)1594-1597
Number of pages4
JournalScience
Volume290
Issue number5496
StatePublished - Nov 24 2000

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Ubiquitins
Yersinia
Peptide Hydrolases
Cysteine Proteases
Post Translational Protein Processing
Ubiquitin
Mitogen-Activated Protein Kinases
Virulence
Cell Death
Proteins

ASJC Scopus subject areas

  • General

Cite this

Orth, K., Xu, Z., Mudgett, M. B., Bao, Z. Q., Palmer, L. E., Bliska, J. B., ... Dixon, J. E. (2000). Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease. Science, 290(5496), 1594-1597.

Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease. / Orth, K.; Xu, Z.; Mudgett, M. B.; Bao, Z. Q.; Palmer, L. E.; Bliska, J. B.; Mangel, W. F.; Staskawicz, B.; Dixon, J. E.

In: Science, Vol. 290, No. 5496, 24.11.2000, p. 1594-1597.

Research output: Contribution to journalArticle

Orth, K, Xu, Z, Mudgett, MB, Bao, ZQ, Palmer, LE, Bliska, JB, Mangel, WF, Staskawicz, B & Dixon, JE 2000, 'Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease', Science, vol. 290, no. 5496, pp. 1594-1597.
Orth K, Xu Z, Mudgett MB, Bao ZQ, Palmer LE, Bliska JB et al. Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease. Science. 2000 Nov 24;290(5496):1594-1597.
Orth, K. ; Xu, Z. ; Mudgett, M. B. ; Bao, Z. Q. ; Palmer, L. E. ; Bliska, J. B. ; Mangel, W. F. ; Staskawicz, B. ; Dixon, J. E. / Disruption of signaling by yersinia effector YopJ, a ubiquitin-like protein protease. In: Science. 2000 ; Vol. 290, No. 5496. pp. 1594-1597.
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