Distinct brain and behavioral benefits from cognitive vs. Physical training: A randomized trial in aging adults

Sandra B. Chapman, Sina Aslan, Jeffrey S. Spence, Molly W. Keebler, Laura F. DeFina, Nyaz Didehbani, Alison M. Perez, Hanzhang Lu, Mark D’Esposito

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Insidious declines in normal aging are well-established. Emerging evidence suggests that non-pharmacological interventions, specifically cognitive and physical training, may counter diminishing age-related cognitive and brain functions. This randomized trial compared effects of two training protocols: Cognitive training (CT) vs. physical training (PT) on cognition and brain function in adults 56-75 years. Sedentary participants (N = 36) were randomized to either CT or PT group for 3 h/week over 12 weeks. They were assessed at baseline-, mid-, and post-training using neurocognitive, MRI, and physiological measures. The CT group improved on executive function whereas PT group’s memory was enhanced. Uniquely deploying cerebral blood flow (CBF) and cerebral vascular reactivity (CVR) MRI, the CT cohort showed increased CBF within the prefrontal and middle/posterior cingulate cortex (PCC) without change to CVR compared to PT group. Improvements in complex abstraction were positively associated with increased resting CBF in dorsal anterior cingulate cortex (dACC). Exercisers with higher CBF in hippocampi bilaterally showed better immediate memory. The preliminary evidence indicates that increased cognitive and physical activity improves brain health in distinct ways. Reasoning training enhanced frontal networks shown to be integral to top-down cognitive control and brain resilience. Evidence of increased resting CBF without changes to CVR implicates increased neural health rather than improved vascular response. Exercise did not improve cerebrovascular response, although CBF increased in hippocampi of those with memory gains. Distinct benefits incentivize testing effectiveness of combined protocols to strengthen brain health.

Original languageEnglish (US)
Article number338
JournalFrontiers in Human Neuroscience
Volume10
DOIs
StatePublished - Jul 18 2016

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Cerebrovascular Circulation
Blood Vessels
Brain
Gyrus Cinguli
Cognition
Hippocampus
Health
Executive Function
Short-Term Memory
Learning

Keywords

  • Aerobic exercise
  • Aging
  • CBF
  • Cognitive training
  • Executive function
  • Memory

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Distinct brain and behavioral benefits from cognitive vs. Physical training : A randomized trial in aging adults. / Chapman, Sandra B.; Aslan, Sina; Spence, Jeffrey S.; Keebler, Molly W.; DeFina, Laura F.; Didehbani, Nyaz; Perez, Alison M.; Lu, Hanzhang; D’Esposito, Mark.

In: Frontiers in Human Neuroscience, Vol. 10, 338, 18.07.2016.

Research output: Contribution to journalArticle

Chapman, Sandra B. ; Aslan, Sina ; Spence, Jeffrey S. ; Keebler, Molly W. ; DeFina, Laura F. ; Didehbani, Nyaz ; Perez, Alison M. ; Lu, Hanzhang ; D’Esposito, Mark. / Distinct brain and behavioral benefits from cognitive vs. Physical training : A randomized trial in aging adults. In: Frontiers in Human Neuroscience. 2016 ; Vol. 10.
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