Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Elisa M. Floriddia; Tânia Lourenço; Shupei Zhang; David van Bruggen; Markus M. Hilscher; Petra Kukanja; João P. Gonçalves dos Santos; Müge Altınkök; Chika Yokota; Enric Llorens-Bobadilla; Sara B. Mulinyawe; Mário Grãos; Lu O. Sun; Jonas Frisén; Mats Nilsson; Gonçalo Castelo-Branco

doi:10.1038/s41467-020-19453-x

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Elisa M. Floriddia, Tânia Lourenço, Shupei Zhang, David van Bruggen, Markus M. Hilscher, Petra Kukanja, João P. Gonçalves dos Santos, Müge Altınkök, Chika Yokota, Enric Llorens-Bobadilla, Sara B. Mulinyawe, Mário Grãos, Lu O. Sun, Jonas Frisén, Mats Nilsson, Gonçalo Castelo-Branco

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease.

Original language	English (US)
Article number	5860
Journal	Nature communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19453-x
State	Published - Dec 2020

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Floriddia, E. M., Lourenço, T., Zhang, S., van Bruggen, D., Hilscher, M. M., Kukanja, P., Gonçalves dos Santos, J. P., Altınkök, M., Yokota, C., Llorens-Bobadilla, E., Mulinyawe, S. B., Grãos, M., Sun, L. O., Frisén, J., Nilsson, M., & Castelo-Branco, G. (2020). Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury. Nature communications, 11(1), Article 5860. https://doi.org/10.1038/s41467-020-19453-x

Floriddia, EM, Lourenço, T, Zhang, S, van Bruggen, D, Hilscher, MM, Kukanja, P, Gonçalves dos Santos, JP, Altınkök, M, Yokota, C, Llorens-Bobadilla, E, Mulinyawe, SB, Grãos, M, Sun, LO, Frisén, J, Nilsson, M & Castelo-Branco, G 2020, 'Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury', Nature communications, vol. 11, no. 1, 5860. https://doi.org/10.1038/s41467-020-19453-x

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abstract = "Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease.",

author = "Floriddia, {Elisa M.} and T{\^a}nia Louren{\c c}o and Shupei Zhang and {van Bruggen}, David and Hilscher, {Markus M.} and Petra Kukanja and {Gon{\c c}alves dos Santos}, {Jo{\~a}o P.} and M{\"u}ge Altınk{\"o}k and Chika Yokota and Enric Llorens-Bobadilla and Mulinyawe, {Sara B.} and M{\'a}rio Gr{\~a}os and Sun, {Lu O.} and Jonas Fris{\'e}n and Mats Nilsson and Gon{\c c}alo Castelo-Branco",

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AU - Floriddia, Elisa M.

AU - Lourenço, Tânia

AU - Zhang, Shupei

AU - van Bruggen, David

AU - Hilscher, Markus M.

AU - Kukanja, Petra

AU - Gonçalves dos Santos, João P.

AU - Altınkök, Müge

AU - Yokota, Chika

AU - Llorens-Bobadilla, Enric

AU - Mulinyawe, Sara B.

AU - Grãos, Mário

AU - Sun, Lu O.

AU - Frisén, Jonas

AU - Nilsson, Mats

AU - Castelo-Branco, Gonçalo

PY - 2020/12

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N2 - Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease.

AB - Mature oligodendrocytes (MOLs) show transcriptional heterogeneity, the functional consequences of which are unclear. MOL heterogeneity might correlate with the local environment or their interactions with different neuron types. Here, we show that distinct MOL populations have spatial preference in the mammalian central nervous system (CNS). We found that MOL type 2 (MOL2) is enriched in the spinal cord when compared to the brain, while MOL types 5 and 6 (MOL5/6) increase their contribution to the OL lineage with age in all analyzed regions. MOL2 and MOL5/6 also have distinct spatial preference in the spinal cord regions where motor and sensory tracts run. OL progenitor cells (OPCs) are not specified into distinct MOL populations during development, excluding a major contribution of OPC intrinsic mechanisms determining MOL heterogeneity. In disease, MOL2 and MOL5/6 present different susceptibility during the chronic phase following traumatic spinal cord injury. Our results demonstrate that the distinct MOL populations have different spatial preference and different responses to disease.

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Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Abstract

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