Distinct pathologic feature of myeloid neoplasm with t(v;11p15); NUP98 rearrangement

Marietya I.S. Lauw, Zhongxia Qi, Lauren Eversmeyer, Sonam Prakash, Kwun Wah Wen, Jingwei Yu, Sara A. Monaghan, Nidhi Aggarwal, Linlin Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosome rearrangements involving NUP98 at 11p15 are rare but recurring abnormalities in acute myeloid leukemia (AML). Here we described 12 cases of myeloid neoplasms with t(v; 11p15); NUP98 rearrangement and characterized their pathologic features. Our patient cohort included 10 adults and 2 children with a median age of 51 years. They were predominantly AML (n = 10) including de novo AML, therapy-related AML, chronic myeloid leukemia with myeloid blast crisis, and mixed phenotype acute leukemia, as well as therapy-related myelodysplastic syndrome (MDS) and MDS/myeloproliferative neoplasm with increased blasts. The blasts shared some common features including pink/red cytoplasmic granules, presence of a perinuclear hof, Auer rods, and occasional bilobed nuclei, mimicking acute promyelocytic leukemia (APML). Flow cytometric studies showed blasts positive for MPO, CD117, CD13 and CD33, with a subset of cases negative for CD34 and/or HLA-DR and a subset of cases expressing monocytic markers. The translocations of 11p15 included t(7; 11) (p15; p15), t(2; 11) (q31; p15), t(9; 11) (p22; p15), t(5; 11) (q32; p15), and t(11; 12) (p15; q13). Three cases showed cryptic NUP98 rearrangement. These patients showed incomplete response to therapy with median overall survival of 17.5 months, a complete remission rate of 25% following chemotherapy induction and primary refractory disease of 58%. It is clinically important to recognize this group of diseases because the blasts can be misclassified as promyelocytes, and NUP98 rearrangement may be cryptic requiring fluorescence in situ hybridization (FISH) study. This case series highlights that NUP98-rearranged myeloid neoplasms are clinically, morphologically, and cytogenetically distinct and could be considered as a separate entity in the WHO classification defined by cytogenetic abnormality.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalHuman Pathology
Volume123
DOIs
StatePublished - May 2022
Externally publishedYes

Keywords

  • Morphology
  • Myeloid neoplasm
  • NUP98 FISH
  • NUP98 rearrangement
  • t(v;11p15)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint

Dive into the research topics of 'Distinct pathologic feature of myeloid neoplasm with t(v;11p15); NUP98 rearrangement'. Together they form a unique fingerprint.

Cite this