Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation

Clayton P. Mosher, Adam N. Mamelak, Mahsa Malekmohammadi, Nader Pouratian, Ueli Rutishauser

Research output: Contribution to journalArticlepeer-review

Abstract

Mosher et al. show that neurons in human dorsal STN participate in movement, while those in ventral STN respond to stop-signals. Stop-signal responses are fast, in line with a race-model of action cancellation and in contrast to beta-bursting that occurs late. Neural activity in STN supports a hyperdirect parcellation of STN into functional zones.

Original languageEnglish (US)
Pages (from-to)869-881.e6
JournalNeuron
Volume109
Issue number5
DOIs
StatePublished - Mar 3 2021
Externally publishedYes

Keywords

  • action cancellation
  • cognitive flexibility
  • human intracranial recordings
  • single-neuron
  • stopping
  • subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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