Distinctive characteristics of non-small cell lung cancer (NSCLC) in the young: A Surveillance, Epidemiology, and End Results (SEER) analysis

Janakiraman Subramanian, Daniel Morgensztern, Boone Goodgame, Maria Q. Baggstrom, Feng Gao, Jay Piccirillo, Ramaswamy Govindan

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Abstract

BACKGROUND: The median age of patients with newly diagnosed non-small cell lung cancer (NSCLC) at presentation is 71 years. We conducted an analysis of Surveillance, Epidemiology, and End Results data to assess whether the presentation and outcomes of NSCLC in younger patients (age ≤40 years) are different from that in older patients (age >40 years). METHODS: We obtained the demographic, clinical, and outcomes data for all patients diagnosed with NSCLC from 1988 to 2003 in the Surveillance, Epidemiology, and End Results registry. Patients were grouped by age at diagnosis into younger than or equal to 40 years (younger cohort) or older than 40 years (older cohort). RESULTS: During the period analyzed, we identified 2775 patients with NSCLC in the younger cohort and 236,313 patients in the older cohort. Compared with the older group, the younger group had greater proportion of African Americans (19.2% versus 10.9%; p < 0.0001), Asian or Pacific Islander (10.3% versus 5.9%; p < 0.0001), women (48.7% versus 41.9%; p < 0.0001), and patients with stage IV disease (57.4% versus 43.0%; p < 0.0001). Adenocarcinoma was more common in younger patients than in the older patients (57.5% versus 45.2%; p < 0.0001). Squamous cell carcinoma was less prevalent in the younger cohort than in older cohort (12.5% versus 26.4%; p < 0.0001). Five-year overall survival and cancer specific survival were significantly better for younger patients than for older patients across all stages. CONCLUSIONS: There is a greater representation of African Americans, Asians or Pacific Islanders, women, and adenocarcinoma histology in the younger cohort of patients with NSCLC compared with the older cohort. Despite presenting with stage IV disease more often, the overall and cancer-specific survivals are better in younger cohort than in the older cohort.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalJournal of Thoracic Oncology
Volume5
Issue number1
DOIs
StatePublished - Jan 2010

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Non-Small Cell Lung Carcinoma
Epidemiology
African Americans
Survival
Adenocarcinoma
Registries
Squamous Cell Carcinoma
Neoplasms
Histology
Demography

Keywords

  • Age less than 40
  • Lung cancer
  • NSCLC
  • Under 40
  • Young patients

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Distinctive characteristics of non-small cell lung cancer (NSCLC) in the young : A Surveillance, Epidemiology, and End Results (SEER) analysis. / Subramanian, Janakiraman; Morgensztern, Daniel; Goodgame, Boone; Baggstrom, Maria Q.; Gao, Feng; Piccirillo, Jay; Govindan, Ramaswamy.

In: Journal of Thoracic Oncology, Vol. 5, No. 1, 01.2010, p. 23-28.

Research output: Contribution to journalArticle

Subramanian, Janakiraman ; Morgensztern, Daniel ; Goodgame, Boone ; Baggstrom, Maria Q. ; Gao, Feng ; Piccirillo, Jay ; Govindan, Ramaswamy. / Distinctive characteristics of non-small cell lung cancer (NSCLC) in the young : A Surveillance, Epidemiology, and End Results (SEER) analysis. In: Journal of Thoracic Oncology. 2010 ; Vol. 5, No. 1. pp. 23-28.
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abstract = "BACKGROUND: The median age of patients with newly diagnosed non-small cell lung cancer (NSCLC) at presentation is 71 years. We conducted an analysis of Surveillance, Epidemiology, and End Results data to assess whether the presentation and outcomes of NSCLC in younger patients (age ≤40 years) are different from that in older patients (age >40 years). METHODS: We obtained the demographic, clinical, and outcomes data for all patients diagnosed with NSCLC from 1988 to 2003 in the Surveillance, Epidemiology, and End Results registry. Patients were grouped by age at diagnosis into younger than or equal to 40 years (younger cohort) or older than 40 years (older cohort). RESULTS: During the period analyzed, we identified 2775 patients with NSCLC in the younger cohort and 236,313 patients in the older cohort. Compared with the older group, the younger group had greater proportion of African Americans (19.2{\%} versus 10.9{\%}; p < 0.0001), Asian or Pacific Islander (10.3{\%} versus 5.9{\%}; p < 0.0001), women (48.7{\%} versus 41.9{\%}; p < 0.0001), and patients with stage IV disease (57.4{\%} versus 43.0{\%}; p < 0.0001). Adenocarcinoma was more common in younger patients than in the older patients (57.5{\%} versus 45.2{\%}; p < 0.0001). Squamous cell carcinoma was less prevalent in the younger cohort than in older cohort (12.5{\%} versus 26.4{\%}; p < 0.0001). Five-year overall survival and cancer specific survival were significantly better for younger patients than for older patients across all stages. CONCLUSIONS: There is a greater representation of African Americans, Asians or Pacific Islanders, women, and adenocarcinoma histology in the younger cohort of patients with NSCLC compared with the older cohort. Despite presenting with stage IV disease more often, the overall and cancer-specific survivals are better in younger cohort than in the older cohort.",
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AU - Subramanian, Janakiraman

AU - Morgensztern, Daniel

AU - Goodgame, Boone

AU - Baggstrom, Maria Q.

AU - Gao, Feng

AU - Piccirillo, Jay

AU - Govindan, Ramaswamy

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N2 - BACKGROUND: The median age of patients with newly diagnosed non-small cell lung cancer (NSCLC) at presentation is 71 years. We conducted an analysis of Surveillance, Epidemiology, and End Results data to assess whether the presentation and outcomes of NSCLC in younger patients (age ≤40 years) are different from that in older patients (age >40 years). METHODS: We obtained the demographic, clinical, and outcomes data for all patients diagnosed with NSCLC from 1988 to 2003 in the Surveillance, Epidemiology, and End Results registry. Patients were grouped by age at diagnosis into younger than or equal to 40 years (younger cohort) or older than 40 years (older cohort). RESULTS: During the period analyzed, we identified 2775 patients with NSCLC in the younger cohort and 236,313 patients in the older cohort. Compared with the older group, the younger group had greater proportion of African Americans (19.2% versus 10.9%; p < 0.0001), Asian or Pacific Islander (10.3% versus 5.9%; p < 0.0001), women (48.7% versus 41.9%; p < 0.0001), and patients with stage IV disease (57.4% versus 43.0%; p < 0.0001). Adenocarcinoma was more common in younger patients than in the older patients (57.5% versus 45.2%; p < 0.0001). Squamous cell carcinoma was less prevalent in the younger cohort than in older cohort (12.5% versus 26.4%; p < 0.0001). Five-year overall survival and cancer specific survival were significantly better for younger patients than for older patients across all stages. CONCLUSIONS: There is a greater representation of African Americans, Asians or Pacific Islanders, women, and adenocarcinoma histology in the younger cohort of patients with NSCLC compared with the older cohort. Despite presenting with stage IV disease more often, the overall and cancer-specific survivals are better in younger cohort than in the older cohort.

AB - BACKGROUND: The median age of patients with newly diagnosed non-small cell lung cancer (NSCLC) at presentation is 71 years. We conducted an analysis of Surveillance, Epidemiology, and End Results data to assess whether the presentation and outcomes of NSCLC in younger patients (age ≤40 years) are different from that in older patients (age >40 years). METHODS: We obtained the demographic, clinical, and outcomes data for all patients diagnosed with NSCLC from 1988 to 2003 in the Surveillance, Epidemiology, and End Results registry. Patients were grouped by age at diagnosis into younger than or equal to 40 years (younger cohort) or older than 40 years (older cohort). RESULTS: During the period analyzed, we identified 2775 patients with NSCLC in the younger cohort and 236,313 patients in the older cohort. Compared with the older group, the younger group had greater proportion of African Americans (19.2% versus 10.9%; p < 0.0001), Asian or Pacific Islander (10.3% versus 5.9%; p < 0.0001), women (48.7% versus 41.9%; p < 0.0001), and patients with stage IV disease (57.4% versus 43.0%; p < 0.0001). Adenocarcinoma was more common in younger patients than in the older patients (57.5% versus 45.2%; p < 0.0001). Squamous cell carcinoma was less prevalent in the younger cohort than in older cohort (12.5% versus 26.4%; p < 0.0001). Five-year overall survival and cancer specific survival were significantly better for younger patients than for older patients across all stages. CONCLUSIONS: There is a greater representation of African Americans, Asians or Pacific Islanders, women, and adenocarcinoma histology in the younger cohort of patients with NSCLC compared with the older cohort. Despite presenting with stage IV disease more often, the overall and cancer-specific survivals are better in younger cohort than in the older cohort.

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KW - Lung cancer

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KW - Under 40

KW - Young patients

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