Distribution of lead in body fluids after ingestion of soft solder

W. I. Manton, C. R. Malloy

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Blood, serum, cerebrospinal fluid, and urine obtained from a patient before and after chelation therapy showed that (1) the ratio of Pb in his cerebrospinal fluid to that in his serum varied from 0.4 to 0.9 and was independent of serum Pb concentration; (2) the fraction of Pb in his serum fell linearly with decreasing blood Pb concentration and changed from 1.6% to 0.33% as his blood Pb concentration changed from 116 μg/dl (5.6 μmol/l) to 31 μg/dl (1.5 μmol/l); and (3) his renal clearance of Pb from serum varied from 5 ml/min to 36 ml/min. This high value was obtained 11 days after chelation and is attributed to large quantities of Sn in his urine promoting the excretion of Pb. Solder was identified in his stool after discovery of radio-opaque material in his bowel. The Pb isotope ratios of the solder were different from those in his urine when he was first admitted, and showed that he had ingested solder when he had returned home on weekend passes.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalBritish Journal of Industrial Medicine
Volume40
Issue number1
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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