Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma

I. Valverde, H. M. Lemon, A. Kessinger, Roger H Unger

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Abstract

Gel filtration of plasma from a patient with a clinical syndrome of glucagonoma and a total plasma glucagon level of 2600 pg/ml, revealed the four glucagon immunoreactive fractions found in normal subjects. The total hyperglucagonemia observed was due to high levels of true glucagon and proglucagon moieties. The so called 'big plasma glucagon' (BPG) measured 109 pg/ml (normal average 113 ± 79 pg/ml, Mean ± (SD), N = 10); the large glucagon immunoreactivity, LGI (9000 mol wt), measured 625 pg/ml (normal average 11 ± 16 pg/ml); the true glucagon accounted for 1435 pg/ml (normal average 31 ± 29 pg/ml); and the small glucagon immunoreactive fraction (2000 mol wt) measured 35 pg/ml (normal average 26 ± 18 pg/ml). The high levels of LGI, considered a candidate for proglucagon, may reflect the increased secretory activity of the tumor.

Original languageEnglish (US)
Pages (from-to)804-808
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume42
Issue number5
Publication statusPublished - 1976

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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