Disturbances in renal autoregulation and the susceptibility to hypertension-induced chronic kidney disease

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31 Citations (Scopus)

Abstract

The risk of developing chronic kidney disease in the setting of hypertension varies among patient populations. Black hypertensive patients have an increased risk of developing hypertension-induced chronic kidney disease even after taking into account socioeconomic factors. There is evidence to suggest that the kidney is intrinsically more susceptible to the damaging effects of hypertension in black patients. This susceptibility can be traced to disturbances in the way the kidney autoregulates. Impaired renal autoregulation may be the renal manifestation of a more widespread abnormality in endothelial function. Other conditions that can impair renal autoregulation and add to the risk of chronic kidney disease include low birth weight, obesity, insulin resistance, hyperuricemia, and hypercholesterolemia. To minimize the risk of chronic kidney disease in patients with impaired renal autoregulatory capability, strict blood pressure control is required. There is indirect evidence that blocking the renin-angiotensin system may improve renal autoregulation.

Original languageEnglish (US)
Pages (from-to)330-343
Number of pages14
JournalAmerican Journal of the Medical Sciences
Volume328
Issue number6
StatePublished - Dec 2004

Fingerprint

Chronic Renal Insufficiency
Homeostasis
Hypertension
Kidney
Hyperuricemia
Low Birth Weight Infant
Renin-Angiotensin System
Hypercholesterolemia
Insulin Resistance
Obesity
Blood Pressure
Population

Keywords

  • Afferent arteriole
  • Endothelial dysfunction
  • Myogenic reflex
  • Racial differences
  • Renal autoregulation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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AB - The risk of developing chronic kidney disease in the setting of hypertension varies among patient populations. Black hypertensive patients have an increased risk of developing hypertension-induced chronic kidney disease even after taking into account socioeconomic factors. There is evidence to suggest that the kidney is intrinsically more susceptible to the damaging effects of hypertension in black patients. This susceptibility can be traced to disturbances in the way the kidney autoregulates. Impaired renal autoregulation may be the renal manifestation of a more widespread abnormality in endothelial function. Other conditions that can impair renal autoregulation and add to the risk of chronic kidney disease include low birth weight, obesity, insulin resistance, hyperuricemia, and hypercholesterolemia. To minimize the risk of chronic kidney disease in patients with impaired renal autoregulatory capability, strict blood pressure control is required. There is indirect evidence that blocking the renin-angiotensin system may improve renal autoregulation.

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