Disturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis

Karina Jandziszak, Carlos Suarez, Ethan Wasserman, Ross Clark, Bonnie Baker, Frances Liu, Raymond Hintz, Paul Saenger, Luc P. Brion

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Abstract

Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum levels of GH, IGFs, and IGF-binding proteins, and the growth response to rGH. CAD was associated with low serum levels of GH in males. Randomized administration of rGH from ~5 to ~12 wk to CAD mice improved food efficiency and increased serum IGF-I levels, final length, and weight compared with placebo without affecting blood pH. Although administration of rGH also increased linear growth in healthy animals, the effect was less than that in CAD mice and was only observed when started before 6 wk of life. Thus growth failure in CAD mice is associated with a decrease in GH secretion in males but not in females. Long-term administration of rGH increases linear growth in CAD mice despite persistent CMA.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume275
Issue number1 44-1
Publication statusPublished - Jul 1998

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Keywords

  • Carbonic anhydrase II deficiency
  • Growth hormone, recombinant
  • Insulin-like growth factor-binding proteins
  • Insulin-like growth factors I and II
  • Renal tubular acidosis
  • Somatotropin

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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