Disturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis

Karina Jandziszak, Carlos Suarez, Ethan Wasserman, Ross Clark, Bonnie Baker, Frances Liu, Raymond Hintz, Paul Saenger, Luc P. Brion

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum levels of GH, IGFs, and IGF-binding proteins, and the growth response to rGH. CAD was associated with low serum levels of GH in males. Randomized administration of rGH from ~5 to ~12 wk to CAD mice improved food efficiency and increased serum IGF-I levels, final length, and weight compared with placebo without affecting blood pH. Although administration of rGH also increased linear growth in healthy animals, the effect was less than that in CAD mice and was only observed when started before 6 wk of life. Thus growth failure in CAD mice is associated with a decrease in GH secretion in males but not in females. Long-term administration of rGH increases linear growth in CAD mice despite persistent CMA.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume275
Issue number1 44-1
StatePublished - Jul 1998

Fingerprint

Somatomedins
Acidosis
Growth Hormone
Growth
Eating
Serum
Somatomedin Receptors
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Osteopetrosis with renal tubular acidosis
Down-Regulation
Placebos
Weights and Measures
Food
Liver

Keywords

  • Carbonic anhydrase II deficiency
  • Growth hormone, recombinant
  • Insulin-like growth factor-binding proteins
  • Insulin-like growth factors I and II
  • Renal tubular acidosis
  • Somatotropin

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Disturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis. / Jandziszak, Karina; Suarez, Carlos; Wasserman, Ethan; Clark, Ross; Baker, Bonnie; Liu, Frances; Hintz, Raymond; Saenger, Paul; Brion, Luc P.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 275, No. 1 44-1, 07.1998.

Research output: Contribution to journalArticle

Jandziszak, Karina ; Suarez, Carlos ; Wasserman, Ethan ; Clark, Ross ; Baker, Bonnie ; Liu, Frances ; Hintz, Raymond ; Saenger, Paul ; Brion, Luc P. / Disturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1998 ; Vol. 275, No. 1 44-1.
@article{cb9a0b189754455abc48a8d3105284cd,
title = "Disturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis",
abstract = "Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum levels of GH, IGFs, and IGF-binding proteins, and the growth response to rGH. CAD was associated with low serum levels of GH in males. Randomized administration of rGH from ~5 to ~12 wk to CAD mice improved food efficiency and increased serum IGF-I levels, final length, and weight compared with placebo without affecting blood pH. Although administration of rGH also increased linear growth in healthy animals, the effect was less than that in CAD mice and was only observed when started before 6 wk of life. Thus growth failure in CAD mice is associated with a decrease in GH secretion in males but not in females. Long-term administration of rGH increases linear growth in CAD mice despite persistent CMA.",
keywords = "Carbonic anhydrase II deficiency, Growth hormone, recombinant, Insulin-like growth factor-binding proteins, Insulin-like growth factors I and II, Renal tubular acidosis, Somatotropin",
author = "Karina Jandziszak and Carlos Suarez and Ethan Wasserman and Ross Clark and Bonnie Baker and Frances Liu and Raymond Hintz and Paul Saenger and Brion, {Luc P.}",
year = "1998",
month = "7",
language = "English (US)",
volume = "275",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1 44-1",

}

TY - JOUR

T1 - Disturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis

AU - Jandziszak, Karina

AU - Suarez, Carlos

AU - Wasserman, Ethan

AU - Clark, Ross

AU - Baker, Bonnie

AU - Liu, Frances

AU - Hintz, Raymond

AU - Saenger, Paul

AU - Brion, Luc P.

PY - 1998/7

Y1 - 1998/7

N2 - Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum levels of GH, IGFs, and IGF-binding proteins, and the growth response to rGH. CAD was associated with low serum levels of GH in males. Randomized administration of rGH from ~5 to ~12 wk to CAD mice improved food efficiency and increased serum IGF-I levels, final length, and weight compared with placebo without affecting blood pH. Although administration of rGH also increased linear growth in healthy animals, the effect was less than that in CAD mice and was only observed when started before 6 wk of life. Thus growth failure in CAD mice is associated with a decrease in GH secretion in males but not in females. Long-term administration of rGH increases linear growth in CAD mice despite persistent CMA.

AB - Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum levels of GH, IGFs, and IGF-binding proteins, and the growth response to rGH. CAD was associated with low serum levels of GH in males. Randomized administration of rGH from ~5 to ~12 wk to CAD mice improved food efficiency and increased serum IGF-I levels, final length, and weight compared with placebo without affecting blood pH. Although administration of rGH also increased linear growth in healthy animals, the effect was less than that in CAD mice and was only observed when started before 6 wk of life. Thus growth failure in CAD mice is associated with a decrease in GH secretion in males but not in females. Long-term administration of rGH increases linear growth in CAD mice despite persistent CMA.

KW - Carbonic anhydrase II deficiency

KW - Growth hormone, recombinant

KW - Insulin-like growth factor-binding proteins

KW - Insulin-like growth factors I and II

KW - Renal tubular acidosis

KW - Somatotropin

UR - http://www.scopus.com/inward/record.url?scp=0031868276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031868276&partnerID=8YFLogxK

M3 - Article

VL - 275

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 1 44-1

ER -