Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

Polina Egorova, Elena Popugaeva, Ilya Bezprozvanny

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer's disease (AD) represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. Abnormal neuronal calcium release from the endoplasmic reticulum may result in disturbances of cell homeostasis, synaptic dysfunction, and eventual cell death. Neuronal loss is observed in most cases of neurodegenerative diseases. Recent experimental evidence supporting the role of neuronal calcium signaling in the pathogenesis of SCAs and AD is discussed in this review.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume40
DOIs
StatePublished - Apr 1 2015

Keywords

  • Alzheimer's disease
  • Ataxia
  • Calcium
  • Polyglutamine expansion disorders
  • Store-operated calcium entry
  • Synapse

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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