Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease

Polina Egorova, Elena Popugaeva, Ilya Bezprozvanny

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Neurodegenerative disorders, such as spinocerebellar ataxias (SCAs) and Alzheimer's disease (AD) represent a huge scientific and medical question, but the molecular mechanisms of these diseases are still not clear. There is increasing evidence that neuronal calcium signaling is abnormal in many neurodegenerative disorders. Abnormal neuronal calcium release from the endoplasmic reticulum may result in disturbances of cell homeostasis, synaptic dysfunction, and eventual cell death. Neuronal loss is observed in most cases of neurodegenerative diseases. Recent experimental evidence supporting the role of neuronal calcium signaling in the pathogenesis of SCAs and AD is discussed in this review.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume40
DOIs
StatePublished - Apr 1 2015

Fingerprint

Spinocerebellar Degenerations
Spinocerebellar Ataxias
Calcium Signaling
Neurodegenerative Diseases
Alzheimer Disease
Endoplasmic Reticulum
Homeostasis
Cell Death
Calcium

Keywords

  • Alzheimer's disease
  • Ataxia
  • Calcium
  • Polyglutamine expansion disorders
  • Store-operated calcium entry
  • Synapse

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease. / Egorova, Polina; Popugaeva, Elena; Bezprozvanny, Ilya.

In: Seminars in Cell and Developmental Biology, Vol. 40, 01.04.2015, p. 127-133.

Research output: Contribution to journalArticle

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