Diuretics as a basis of antihypertensive therapy

An overview

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Diuretics have been, except for during a few recent years, the most commonly used therapy for hypertension. Although use of these agents fell significantly in the early 1990s, since then it has begun to increase again. Their recent return to popularity reflects 3 major factors: (i) recognition of the effectiveness of much lower dosages than previously used, thereby providing good antihypertensive activity with fewer adverse effects; (ii) the excellent reductions in morbidity and mortality achieved by low dosage diuretic-based therapy in multiple randomised controlled trials in elderly patients with hypertension; and (iii) the increasing recognition that some diuretic-induced shrinkage of effective blood volume is essential for the adequate treatment of many, if not most, patients with hypertension. Therefore, diuretics will probably continue to be the basis for antihypertensive therapy, and the indapamide sustained release 1.5mg formulation provides all the essential characteristics of diuretic therapy.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalDrugs
Volume59
Issue numberSUPPL. 2
StatePublished - 2000

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Diuretics
Antihypertensive Agents
Hypertension
Indapamide
Therapeutics
Blood Volume
Blood
Randomized Controlled Trials
Morbidity
Mortality

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Diuretics as a basis of antihypertensive therapy : An overview. / Kaplan, Norman M.

In: Drugs, Vol. 59, No. SUPPL. 2, 2000, p. 21-25.

Research output: Contribution to journalArticle

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