Abstract
The use of diuretics for the treatment of hypertension had fallen significantly from 1990 until 1997, when their use again began to increase. Their recent return to popularity reflects 3 major factors: (1) the recognition of the effectiveness of much lower doses than used previously, thereby providing good antihypertensive action with fewer side effects; (2) the excellent reductions in morbidity and mortality achieved by low-dose diuretic-based therapy in multiple, randomized controlled trials in elderly hypertensives; and (3) the increasing recognition that some diuretic-induced shrinkage of effective blood volume is essential for adequate treatment of many, if not most, hypertensives.
Original language | English (US) |
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Pages (from-to) | 559-574 |
Number of pages | 16 |
Journal | Seminars in nephrology |
Volume | 19 |
Issue number | 6 |
State | Published - Dec 1 1999 |
ASJC Scopus subject areas
- Nephrology