The use of diuretics for the treatment of hypertension had fallen significantly from 1990 until 1997, when their use again began to increase. Their recent return to popularity reflects 3 major factors: (1) the recognition of the effectiveness of much lower doses than used previously, thereby providing good antihypertensive action with fewer side effects; (2) the excellent reductions in morbidity and mortality achieved by low-dose diuretic-based therapy in multiple, randomized controlled trials in elderly hypertensives; and (3) the increasing recognition that some diuretic-induced shrinkage of effective blood volume is essential for adequate treatment of many, if not most, hypertensives.
|Original language||English (US)|
|Number of pages||16|
|Journal||Seminars in nephrology|
|State||Published - Dec 1 1999|
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