Diverse classes of T-cell lymphomas arise in T-lymphocyte-inductive epitheliomas of the mouse salivary gland

Florence A. Harrod, John R. Kettman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

During the course of serial transplantations of polyomavirus-induced C3H-Bittner salivary gland epitheliomas in F1-hybrid mice, three tumor sublines were found which gave rise to T-cell lymphomas of host origin. The lymphomas resembled spontaneous AKR/J thymic lymphomas in their expression of lymphoid differentiation antigens, and they may represent sequential stages in the differentiation of immature T lymphocytes. We found no evidence that polyomavirus directly induced the lymphomas, rather, the lymphomagenic events paralleled those which occur in spontaneous AKR/J thymic lymphomas.

Original languageEnglish (US)
Pages (from-to)899-917
Number of pages19
JournalLeukemia Research
Volume16
Issue number9
DOIs
StatePublished - Sep 1992

Keywords

  • MuLV
  • T-cell lymphomas
  • polyomavirus
  • salivary gland epitheliomas
  • thymocytes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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