Abstract
Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to change chromatin structures and regulate nuclear processes such as transcription. BAF complexes contain multiple subunits and the diverse subunit compositions provide functional specificities to BAF complexes. In this review, we summarize the functions of BAF subunits during mammalian development and in progression of various cancers. The mechanisms underlying the functional diversity and specificities of BAF complexes will be discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 54-69 |
| Number of pages | 16 |
| Journal | Acta Biochimica et Biophysica Sinica |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
Keywords
- ATP-dependent chromatin remodeling
- BAF
- SWI/SNF
- cancer
- development
ASJC Scopus subject areas
- Biophysics
- Biochemistry