Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer

Research output: Contribution to journalReview article

64 Scopus citations

Abstract

Mammalian SWI/SNF like Brg1/Brm associated factors (BAF) chromatin-remodeling complexes are able to use energy derived from adenosine triphosphate (ATP) hydrolysis to change chromatin structures and regulate nuclear processes such as transcription. BAF complexes contain multiple subunits and the diverse subunit compositions provide functional specificities to BAF complexes. In this review, we summarize the functions of BAF subunits during mammalian development and in progression of various cancers. The mechanisms underlying the functional diversity and specificities of BAF complexes will be discussed.

Original languageEnglish (US)
Pages (from-to)54-69
Number of pages16
JournalActa Biochimica et Biophysica Sinica
Volume44
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • ATP-dependent chromatin remodeling
  • BAF
  • SWI/SNF
  • cancer
  • development

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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