Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization

Peter Lamb; Steven L. McKnight

doi:10.1016/0968-0004(91)90167-T

Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization

Peter Lamb, Steven L. McKnight

Research output: Contribution to journal › Article › peer-review

305 Scopus citations

Abstract

Many eukaryotic transcription factors contain domains that mediate the formation of homo- and heterodimers. The widespread occurrence of such domains suggests that they are important to the genetic regulatory apparatus. In this review we explore the contributions that heterotypic dimerization may make to the generation of regulatory diversity.

Original language	English (US)
Pages (from-to)	417-422
Number of pages	6
Journal	Trends in biochemical sciences
Volume	16
Issue number	C
DOIs	https://doi.org/10.1016/0968-0004(91)90167-T
State	Published - 1991

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/0968-0004(91)90167-T

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title = "Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization",

abstract = "Many eukaryotic transcription factors contain domains that mediate the formation of homo- and heterodimers. The widespread occurrence of such domains suggests that they are important to the genetic regulatory apparatus. In this review we explore the contributions that heterotypic dimerization may make to the generation of regulatory diversity.",

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AU - McKnight, Steven L.

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AB - Many eukaryotic transcription factors contain domains that mediate the formation of homo- and heterodimers. The widespread occurrence of such domains suggests that they are important to the genetic regulatory apparatus. In this review we explore the contributions that heterotypic dimerization may make to the generation of regulatory diversity.

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JO - Trends in biochemical sciences

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Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization

Abstract

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