Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization

Peter Lamb, Steven L. McKnight

Research output: Contribution to journalArticle

245 Scopus citations

Abstract

Many eukaryotic transcription factors contain domains that mediate the formation of homo- and heterodimers. The widespread occurrence of such domains suggests that they are important to the genetic regulatory apparatus. In this review we explore the contributions that heterotypic dimerization may make to the generation of regulatory diversity.

Original languageEnglish (US)
Pages (from-to)417-422
Number of pages6
JournalTrends in Biochemical Sciences
Volume16
Issue numberC
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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