Diversity in modern heart failure trials: Where are we, and where are we going

Uzoma Anaba, Abiodun Ishola, Alisha Alabre, Albert Bui, Marloe Prince, Henry Okafor, Onaopepo Kola-Kehinde, Joshua J. Joseph, Darrion Mitchell, Bismarck C. Odei, Anezi Uzendu, Karen Patricia Williams, Quinn Capers, Daniel Addison

Research output: Contribution to journalArticlepeer-review

Abstract

Over the last three decades, increased attention has been given to the representation of historically underrepresented groups within the landscape of pivotal clinical trials. However, recent events (i.e., coronavirus pandemic) have laid bare the potential continuation of historic inequities in available clinical trials and studies aimed at the care of broad patient populations. Anecdotally, cardiovascular disease (CVD) has not been immune to these disparities. Within this review, we examine and discuss recent landmark CVD trials, with a specific focus on the representation of Blacks within several critically foundational heart failure clinical trials tied to contemporary treatment strategies and drug approvals. We also discuss solutions for inequities within the landscape of cardiovascular trials. Building a more diverse clinical trial workforce coupled with intentional efforts to increase clinical trial diversity will advance equity in cardiovascular care.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalInternational Journal of Cardiology
Volume348
DOIs
StatePublished - Feb 1 2022
Externally publishedYes

Keywords

  • Black
  • Cardiovascular clinical trials
  • Disparities

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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