Diversity of Polyubiquitin Chains

Anirban Adhikari; Zhijian J. Chen

doi:10.1016/j.devcel.2009.04.001

Diversity of Polyubiquitin Chains

Anirban Adhikari, Zhijian J. Chen

Research output: Contribution to journal › Short survey › peer-review

58 Scopus citations

Abstract

Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD).

Original language	English (US)
Pages (from-to)	485-486
Number of pages	2
Journal	Developmental cell
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2009.04.001
State	Published - Apr 21 2009

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2009.04.001

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abstract = "Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD).",

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AU - Chen, Zhijian J.

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AB - Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can target proteasomal degradation in vivo, and that lysine-11 polyubiquitination is important for endoplasmic reticulum-associated degradation (ERAD).

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M3 - Short survey

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JO - Developmental cell

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Diversity of Polyubiquitin Chains

Abstract

ASJC Scopus subject areas

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