DNA damage and its links to neurodegeneration

Ram Madabhushi, Ling Pan, Li Huei Tsai

Research output: Contribution to journalReview article

180 Citations (Scopus)

Abstract

The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the consequences of genomic instability in the nervous system. We highlight the neuropathology of congenital syndromes that result from mutations in DNA repair factors and underscore the importance of the DNA damage response in neural development. In addition, we describe the findings of recent studies, which reveal that a robust DNA damage response is also intimately connected to aging and the manifestation of age-related neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis. Video Abstract: In this Review, Madabhushi etal. summarize the current state of knowledge about how DNA damage and changes to the DNA damage response in neurons might underlie neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)266-282
Number of pages17
JournalNeuron
Volume83
Issue number2
DOIs
StatePublished - Jul 16 2014

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DNA Damage
Neurodegenerative Diseases
Nervous System
Genomic Instability
Amyotrophic Lateral Sclerosis
DNA Repair
Alzheimer Disease
Neurons
Mutation
Genes
Neoplasms

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

DNA damage and its links to neurodegeneration. / Madabhushi, Ram; Pan, Ling; Tsai, Li Huei.

In: Neuron, Vol. 83, No. 2, 16.07.2014, p. 266-282.

Research output: Contribution to journalReview article

Madabhushi, Ram ; Pan, Ling ; Tsai, Li Huei. / DNA damage and its links to neurodegeneration. In: Neuron. 2014 ; Vol. 83, No. 2. pp. 266-282.
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