DNA damage and repair

Errol C. Friedberg

doi:10.1038/nature01408

DNA damage and repair

Errol C. Friedberg

Research output: Chapter in Book/Report/Conference proceeding › Chapter

328 Scopus citations

Abstract

The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is sUbject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution.

Original language	English (US)
Title of host publication	50 Years of DNA
Publisher	Palgrave Macmillan
Pages	122-126
Number of pages	5
ISBN (Electronic)	9781137117816
ISBN (Print)	9781403914804
DOIs	https://doi.org/10.1038/nature01408
State	Published - Jan 1 2016

ASJC Scopus subject areas

General Arts and Humanities

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10.1038/nature01408

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DNA damage and repair

Abstract

ASJC Scopus subject areas

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