DNA damage and repair

Research output: Chapter in Book/Report/Conference proceedingChapter

239 Scopus citations

Abstract

The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is sUbject to continuous damage and the cell has an arsenal of ways of responding to such injury. Although mutations or deficiencies in repair can have catastrophic consequences, causing a range of human diseases, mutations are nonetheless fundamental to life and evolution.

Original languageEnglish (US)
Title of host publication50 Years of DNA
PublisherPalgrave Macmillan
Pages122-126
Number of pages5
ISBN (Electronic)9781137117816
ISBN (Print)9781403914804
DOIs
StatePublished - Jan 1 2016

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ASJC Scopus subject areas

  • Arts and Humanities(all)

Cite this

Friedberg, E. C. (2016). DNA damage and repair. In 50 Years of DNA (pp. 122-126). Palgrave Macmillan. https://doi.org/10.1038/nature01408