DNA-dependent protein kinase in nonhomologous end joining: A lock with multiple keys?

Eric Weterings, David J. Chen

Research output: Contribution to journalShort survey

85 Scopus citations

Abstract

The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalJournal of Cell Biology
Volume179
Issue number2
DOIs
StatePublished - Oct 22 2007

ASJC Scopus subject areas

  • Cell Biology

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