DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

Keri Martinowich, Daisuke Hattori, Hao Wu, Shaun Fouse, Fei He, Yan Hu, Guoping Fan, Yi E. Sun

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Abstract

In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG-binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter. Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity.

Original languageEnglish (US)
Pages (from-to)890-893
Number of pages4
JournalScience
Volume302
Issue number5646
DOIs
Publication statusPublished - Oct 31 2003
Externally publishedYes

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Cite this

Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., ... Sun, Y. E. (2003). DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation. Science, 302(5646), 890-893. https://doi.org/10.1126/science.1090842