DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

Keri Martinowich, Daisuke Hattori, Hao Wu, Shaun Fouse, Fei He, Yan Hu, Guoping Fan, Yi E. Sun

Research output: Contribution to journalArticle

1018 Citations (Scopus)

Abstract

In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG-binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the Bdnf gene. Moreover, increased Bdnf transcription involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter. Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity.

Original languageEnglish (US)
Pages (from-to)890-893
Number of pages4
JournalScience
Volume302
Issue number5646
DOIs
StatePublished - Oct 31 2003
Externally publishedYes

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Chromatin Assembly and Disassembly
DNA Methylation
Histone Code
Genes
Rett Syndrome
Neuronal Plasticity
Histone Deacetylases
Nucleic Acid Regulatory Sequences
Brain-Derived Neurotrophic Factor
Gene Silencing
Methylation
Carrier Proteins
Neurons
Mutation

ASJC Scopus subject areas

  • General

Cite this

Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., ... Sun, Y. E. (2003). DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation. Science, 302(5646), 890-893. https://doi.org/10.1126/science.1090842

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation. / Martinowich, Keri; Hattori, Daisuke; Wu, Hao; Fouse, Shaun; He, Fei; Hu, Yan; Fan, Guoping; Sun, Yi E.

In: Science, Vol. 302, No. 5646, 31.10.2003, p. 890-893.

Research output: Contribution to journalArticle

Martinowich, K, Hattori, D, Wu, H, Fouse, S, He, F, Hu, Y, Fan, G & Sun, YE 2003, 'DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation', Science, vol. 302, no. 5646, pp. 890-893. https://doi.org/10.1126/science.1090842
Martinowich, Keri ; Hattori, Daisuke ; Wu, Hao ; Fouse, Shaun ; He, Fei ; Hu, Yan ; Fan, Guoping ; Sun, Yi E. / DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation. In: Science. 2003 ; Vol. 302, No. 5646. pp. 890-893.
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