DNA mismatch repair: Biological functions and molecular mechanisms

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

DNA mismatch repair (MMR) is an important genome caretaker system. It ensures genomic stability by correcting mismatches generated during DNA replication and recombination, suppressing homeologous recombination, and triggering apoptosis of cells with severe DNA damage. Protein components required for these reactions are highly conserved through evolution, and MutS-like and MutL-like proteins in mammalian cells are key players responsible for the initiation steps of both the strand-specific mismatch correction and the MMR-dependent apoptotic signaling. The inactivation of the genes encoding these activities leads to genome-wide instability, particularly in simple repetitive sequences, and the predisposition to certain types of cancer, including hereditary non-polyposis colorectal cancer.

Original languageEnglish (US)
Title of host publicationDNA Repair, Genetic Instability, and Cancer
PublisherWorld Scientific Publishing Co.
Pages87-117
Number of pages31
ISBN (Electronic)9789812706782
ISBN (Print)9789812700148
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Li, G. M. (2007). DNA mismatch repair: Biological functions and molecular mechanisms. In DNA Repair, Genetic Instability, and Cancer (pp. 87-117). World Scientific Publishing Co.. https://doi.org/10.1142/9789812706782_0004