DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential

Yaping Huang, Guo Min Li

Research output: Contribution to journalReview articlepeer-review

Abstract

DNA mismatch repair (MMR) maintains genomic stability primarily by correcting replication errors. Defects in MMR lead to cancers and cause resistance to many chemotherapeutic drugs. Emerging evidence reveals that MMR is coupled with replication and precisely regulated in the context of chromatin; strikingly, tumors defective in MMR are highly responsive to immune checkpoint blockade therapy. As a tribute to Dr. Samuel Wilson for his many scientific contributions to the field of DNA repair and his leadership as Editor-in-Chief of the journal DNA Repair, we summarize recent developments in research on MMR at the chromatin level, its implications for tumorigenesis, and its therapeutic potential.

Original languageEnglish (US)
Article number102918
JournalDNA repair
Volume93
DOIs
StatePublished - Sep 2020

Keywords

  • Cancer therapy
  • Chromatin structure
  • Mimsatch repair
  • Replication fork

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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