DNA mismatch repair in the context of chromatin

Yaping Huang, Guo Min Li

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MMR deficiency and its role in tumorigenesis. This review summarizes these chromatin-level mechanisms that regulate MMR and their implications for tumor development.

Original languageEnglish (US)
Article number10
JournalCell and Bioscience
Volume10
Issue number1
DOIs
StatePublished - Feb 3 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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