DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

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157 Scopus citations

Abstract

DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalDNA repair
Volume17
DOIs
StatePublished - May 2014

Keywords

  • DNA double strand breaks
  • DNA ligase IV
  • DNA-PKcs
  • Ku70/80
  • Non-homologous end-joining
  • XLF
  • XRCC4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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