DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalDNA Repair
Volume17
DOIs
StatePublished - 2014

Fingerprint

Joining
Repair
Double-Stranded DNA Breaks
Genomic Instability
DNA
Enzymes
DNA Repair
Ligation
Carcinogenesis
Proteins
Molecules

Keywords

  • DNA double strand breaks
  • DNA ligase IV
  • DNA-PKcs
  • Ku70/80
  • Non-homologous end-joining
  • XLF
  • XRCC4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Medicine(all)

Cite this

DNA-PK : A dynamic enzyme in a versatile DSB repair pathway. / Davis, Anthony J.; Chen, Benjamin P C; Chen, David J.

In: DNA Repair, Vol. 17, 2014, p. 21-29.

Research output: Contribution to journalArticle

@article{b6151bcf5f764746afaf044ad31447b7,
title = "DNA-PK: A dynamic enzyme in a versatile DSB repair pathway",
abstract = "DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.",
keywords = "DNA double strand breaks, DNA ligase IV, DNA-PKcs, Ku70/80, Non-homologous end-joining, XLF, XRCC4",
author = "Davis, {Anthony J.} and Chen, {Benjamin P C} and Chen, {David J.}",
year = "2014",
doi = "10.1016/j.dnarep.2014.02.020",
language = "English (US)",
volume = "17",
pages = "21--29",
journal = "DNA Repair",
issn = "1568-7864",
publisher = "Elsevier",

}

TY - JOUR

T1 - DNA-PK

T2 - A dynamic enzyme in a versatile DSB repair pathway

AU - Davis, Anthony J.

AU - Chen, Benjamin P C

AU - Chen, David J.

PY - 2014

Y1 - 2014

N2 - DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.

AB - DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.

KW - DNA double strand breaks

KW - DNA ligase IV

KW - DNA-PKcs

KW - Ku70/80

KW - Non-homologous end-joining

KW - XLF

KW - XRCC4

UR - http://www.scopus.com/inward/record.url?scp=84900458715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900458715&partnerID=8YFLogxK

U2 - 10.1016/j.dnarep.2014.02.020

DO - 10.1016/j.dnarep.2014.02.020

M3 - Article

C2 - 24680878

AN - SCOPUS:84900458715

VL - 17

SP - 21

EP - 29

JO - DNA Repair

JF - DNA Repair

SN - 1568-7864

ER -