Do adaptive immune cells suppress or activate innate immunity?

Jie Zhao, Xuanming Yang, Sogyong L. Auh, Kwang Dong Kim, Hong Tang, Yang Xin Fu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Current dogma holds that the innate immune system primes the adaptive immune system in response to infection, which in turn amplifies innate responses in a positive loop to effectively control pathogens. Therefore, it is accepted in most cases that T-cell deficient hosts die of acute infection because of the impaired ability of the innate immune system to control pathogens. Recent studies, however, reveal that adaptive immune cells actively dampen initial innate responses. In contrast to current understanding, there is now evidence that an insufficient number of T cells results in loss of control of innate immune responses. This raises new questions regarding the, as of yet underappreciated, role of the adaptive immune system in early infection and inflammation.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalTrends in Immunology
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2009

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Innate Immunity
Immune System
Infection
T-Lymphocytes
Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Do adaptive immune cells suppress or activate innate immunity? / Zhao, Jie; Yang, Xuanming; Auh, Sogyong L.; Kim, Kwang Dong; Tang, Hong; Fu, Yang Xin.

In: Trends in Immunology, Vol. 30, No. 1, 01.01.2009, p. 8-12.

Research output: Contribution to journalArticle

Zhao, Jie ; Yang, Xuanming ; Auh, Sogyong L. ; Kim, Kwang Dong ; Tang, Hong ; Fu, Yang Xin. / Do adaptive immune cells suppress or activate innate immunity?. In: Trends in Immunology. 2009 ; Vol. 30, No. 1. pp. 8-12.
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