Do atypical antipsychotic agents trigger autoimmune diabetes?

Benjamin U. Nwosu, Olga T. Hardy, Amanda Angelescu, Leslie A. Soyka, Mary M. Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Atypical or second-generation antipsychotic agents, such as aripiprazole and olanzapine, are increasingly used in the management of schizophrenia and bipolar disorders in children. The atypical antipsychotic agents have been associated with the development of hyperglycemia, ketoacidosis, and diabetes. The mechanism of atypical antipsychotic-mediated hyperglycemia is unclear. Most of the published reports have been on individuals at risk for type 2 diabetes. We present the first known cases of the development of diabetes and positive glutamic acid decarboxylase antibodies (suggestive of autoimmune diabetes) in adolescents while on treatment with atypical antipsychotics. The nature of their clinical presentations and the time course of antipsychotic therapy to clinical diagnosis of diabetes make us speculate that atypical antipsychotics may shorten the time course of the development of autoimmune diabetes in predisposed children.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalEndocrinologist
Volume19
Issue number2
DOIs
StatePublished - Mar 2009

Fingerprint

Type 1 Diabetes Mellitus
Antipsychotic Agents
olanzapine
Hyperglycemia
Ketosis
Glutamate Decarboxylase
Bipolar Disorder
Type 2 Diabetes Mellitus
Schizophrenia
Antibodies
Therapeutics

Keywords

  • Atypical antipsychotics
  • Autoimmune diabetes
  • Diabetic ketoacidosis
  • Hyperglycemia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Do atypical antipsychotic agents trigger autoimmune diabetes? / Nwosu, Benjamin U.; Hardy, Olga T.; Angelescu, Amanda; Soyka, Leslie A.; Lee, Mary M.

In: Endocrinologist, Vol. 19, No. 2, 03.2009, p. 85-87.

Research output: Contribution to journalArticle

Nwosu, Benjamin U. ; Hardy, Olga T. ; Angelescu, Amanda ; Soyka, Leslie A. ; Lee, Mary M. / Do atypical antipsychotic agents trigger autoimmune diabetes?. In: Endocrinologist. 2009 ; Vol. 19, No. 2. pp. 85-87.
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