Does earlier lobectomy result in better long-term pulmonary function in children with congenital lung anomalies? A prospective study

Yoko Naito, Alana Beres, Eveline Lapidus-Krol, Felix Ratjen, Jacob C. Langer

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Management of asymptomatic congenital pulmonary airway malformations remains controversial when addressing the optimal timing of surgical resection. Neonatal resection is advocated by some based on the theory that earlier lobectomy results in greater compensatory lung growth. We examined whether age at lobectomy is correlated with better pulmonary outcomes as reflected by pulmonary function and exercise testing. Methods: Patients who had lobectomy for congenital pulmonary airway malformation between 1985 and 2002 were identified and underwent detailed clinical history, physical examination, pulmonary function testing (total lung capacity, forced vital capacity, forced expiratory volume in 1 second), and exercise testing (power, maximal oxygen uptake [Vo 2max]). Results: Of 87 patients identified, 47 met the inclusion criteria, and 28 were tested prospectively. Age at the time of lobectomy ranged from 3 days to 56 months. There was no correlation between age at lobectomy and pulmonary function (total lung capacity, P =.408; forced vital capacity, P =.319; forced expiratory volume in 1 second, P =.174) or maximal work capacity (power, P =.280). There was a trend toward lower Vo 2max in patients who had undergone lobectomy at an older age (Vo 2max, P =.055). Conclusion: Most children undergoing lobectomy have normal long-term pulmonary function. We found no correlation between age at lobectomy and future pulmonary function. Cardiopulmonary exercise testing should be considered in evaluating functional outcome in these patients.

Original languageEnglish (US)
Pages (from-to)852-856
Number of pages5
JournalJournal of Pediatric Surgery
Volume47
Issue number5
DOIs
StatePublished - May 1 2012

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Prospective Studies
Lung
Total Lung Capacity
Vital Capacity
Forced Expiratory Volume
Exercise
Physical Examination
Oxygen
Growth

Keywords

  • Cardiopulmonary exercise test
  • Congenital pulmonary airway malformation
  • Lobectomy
  • Pulmonary function test

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Does earlier lobectomy result in better long-term pulmonary function in children with congenital lung anomalies? A prospective study. / Naito, Yoko; Beres, Alana; Lapidus-Krol, Eveline; Ratjen, Felix; Langer, Jacob C.

In: Journal of Pediatric Surgery, Vol. 47, No. 5, 01.05.2012, p. 852-856.

Research output: Contribution to journalArticle

Naito, Yoko ; Beres, Alana ; Lapidus-Krol, Eveline ; Ratjen, Felix ; Langer, Jacob C. / Does earlier lobectomy result in better long-term pulmonary function in children with congenital lung anomalies? A prospective study. In: Journal of Pediatric Surgery. 2012 ; Vol. 47, No. 5. pp. 852-856.
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