Does Helicobacter pylori infection contribute to gastroesophageal reflux disease?

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Helicobacter pylori organisms that infect the stomach conceivably could contribute to esophageal inflammation in patients with gastroesophageal reflux disease (GERD) through any of at least three potential mechanisms: 1) by causing an increase in gastric acid secretion; 2) by spreading to infect the gastric-type columnar epithelium that occasionally can line the distal esophagus; and/or 3) by secreting noxious bacterial products into the gastric juice. Studies regarding these potential mechanisms are discussed in this report. Most investigations have found no apparent association between H. pylori infection and reflux esophagitis. Presently, infection with H. pylori does not appear to play an important role in the pathogenesis of GERD.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalYale Journal of Biology and Medicine
Volume71
Issue number2
StatePublished - 1998

Fingerprint

Helicobacter Infections
Gastroesophageal Reflux
Helicobacter pylori
Stomach
Peptic Esophagitis
Gastric Juice
Gastric Acid
Esophagus
Acids
Epithelium
Inflammation
Infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Does Helicobacter pylori infection contribute to gastroesophageal reflux disease? / Spechler, S. J.

In: Yale Journal of Biology and Medicine, Vol. 71, No. 2, 1998, p. 143-148.

Research output: Contribution to journalArticle

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