Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Clayton R. Hunt; Arun Gupta; Nobuo Horikoshi; Tej K. Pandita

doi:10.1158/1078-0432.CCR-11-3131

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Clayton R. Hunt, Arun Gupta, Nobuo Horikoshi, Tej K. Pandita

Radiation Oncology

Research output: Contribution to journal › Comment/debate › peer-review

29 Scopus citations

Abstract

The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity.

Original language	English (US)
Pages (from-to)	920-922
Number of pages	3
Journal	Clinical Cancer Research
Volume	18
Issue number	4
DOIs	https://doi.org/10.1158/1078-0432.CCR-11-3131
State	Published - Feb 15 2012

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1158/1078-0432.CCR-11-3131

Cite this

@article{5da231e4253646c18d683798be825f4d,

title = "Does PTEN loss impair DNA double-strand break repair by homologous recombination?",

abstract = "The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity.",

author = "Hunt, {Clayton R.} and Arun Gupta and Nobuo Horikoshi and Pandita, {Tej K.}",

year = "2012",

month = feb,

day = "15",

doi = "10.1158/1078-0432.CCR-11-3131",

language = "English (US)",

volume = "18",

pages = "920--922",

journal = "Clinical Cancer Research",

issn = "1078-0432",