Dominant-side intracarotid amobarbital spares comprehension of word meaning

J. Hart, R. P. Lesser, R. S. Fisher, P. Schwerdt, R. N. Bryan, B. Gordon

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Abolition of speech production after intracarotid amobarbital injection is generally considered evidence for language laterality. However, complex auditory comprehension may be preserved after injection of the dominant (left) side. The possibility that this sparing may be due to the intracarotid amobarbital injection not adequately deactivating some of the areas responsible for speech comprehension in the posterior part of the hemisphere was tested with a task known to be critically dependent on the left posterotemporal-inferoparietal region, one assessing visuoverbal semanticrelatedness. Even when the intracarotid injection of the left side produced marked deficits of speech production, comprehension of semantic relations was still intact in eight of 15 patients. Ten of these 15 patients also received right carotid injections, none of which affected comprehension of semantic relatedness. These data indicate that the intracarotid amobarbital injection cannot always specify the laterality of all language functions, an important concern when considering surgical procedures in the dominant posterotemporal-inferoparietal region.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalArchives of Neurology
Volume48
Issue number1
StatePublished - 1991

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Amobarbital
Injections
Semantics
Language
Word Meaning
Speech Production
Laterality

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hart, J., Lesser, R. P., Fisher, R. S., Schwerdt, P., Bryan, R. N., & Gordon, B. (1991). Dominant-side intracarotid amobarbital spares comprehension of word meaning. Archives of Neurology, 48(1), 55-58.

Dominant-side intracarotid amobarbital spares comprehension of word meaning. / Hart, J.; Lesser, R. P.; Fisher, R. S.; Schwerdt, P.; Bryan, R. N.; Gordon, B.

In: Archives of Neurology, Vol. 48, No. 1, 1991, p. 55-58.

Research output: Contribution to journalArticle

Hart, J, Lesser, RP, Fisher, RS, Schwerdt, P, Bryan, RN & Gordon, B 1991, 'Dominant-side intracarotid amobarbital spares comprehension of word meaning', Archives of Neurology, vol. 48, no. 1, pp. 55-58.
Hart J, Lesser RP, Fisher RS, Schwerdt P, Bryan RN, Gordon B. Dominant-side intracarotid amobarbital spares comprehension of word meaning. Archives of Neurology. 1991;48(1):55-58.
Hart, J. ; Lesser, R. P. ; Fisher, R. S. ; Schwerdt, P. ; Bryan, R. N. ; Gordon, B. / Dominant-side intracarotid amobarbital spares comprehension of word meaning. In: Archives of Neurology. 1991 ; Vol. 48, No. 1. pp. 55-58.
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