Donor-derived disease transmission events in the united states: Data reviewed by the OPTN/UNOS disease transmission advisory committee

M. G. Ison, J. Hager, E. Blumberg, J. Burdick, K. Carney, J. Cutler, J. M. Dimaio, R. Hasz, M. J. Kuehnert, E. Ortiz-Rios, L. Teperman, M. Nalesnik

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Donor-derived disease transmission is increasingly recognized as a source of morbidity and mortality among transplant recipients. Policy 4.7 of the Organ Procurement and Transplantation Network (OPTN) currently requires reporting of donor-derived events. All potential donor-derived transmission events (PDDTE) reported to OPTN/UNOS were reviewed by the Disease Transmission Advisory Committee (DTAC). Summary data from January 1, 2005-December 31, 2007, were prepared for presentation. Reports of PDDTE have increased from 7 in 2005, the first full year data were collected, to 60 in 2006 and to 97 in 2007. More detailed information is available for 2007; a classification system for determining likelihood of donor-derived transmission was utilized. In 2007, there were four proven and one possible donor-derived malignancy transmissions and four proven, two probable and six possible donor-derived infectious diseases transmissions. There were nine reported recipient deaths attributable to proven donor transmissions events arising from eight donors during 2007. Although recognized transmission events resulted in significant morbidity and mortality, transmission was reported in only 0.96% of deceased donor donations overall. Improved reporting, through enhanced recognition and communication, will be critical to better estimate the transmission risk of infection and malignancy through organ transplantation.

Original languageEnglish (US)
Pages (from-to)1929-1935
Number of pages7
JournalAmerican Journal of Transplantation
Volume9
Issue number8
DOIs
StatePublished - Aug 2009

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Tissue and Organ Procurement
Organ Transplantation
Advisory Committees
Tissue Donors
Infectious Disease Transmission
Morbidity
Mortality
Neoplasms
Communication

Keywords

  • Donor risk
  • Donor-to-host transmission
  • Infectious diseases
  • Malignancy

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

Cite this

Donor-derived disease transmission events in the united states : Data reviewed by the OPTN/UNOS disease transmission advisory committee. / Ison, M. G.; Hager, J.; Blumberg, E.; Burdick, J.; Carney, K.; Cutler, J.; Dimaio, J. M.; Hasz, R.; Kuehnert, M. J.; Ortiz-Rios, E.; Teperman, L.; Nalesnik, M.

In: American Journal of Transplantation, Vol. 9, No. 8, 08.2009, p. 1929-1935.

Research output: Contribution to journalArticle

Ison, MG, Hager, J, Blumberg, E, Burdick, J, Carney, K, Cutler, J, Dimaio, JM, Hasz, R, Kuehnert, MJ, Ortiz-Rios, E, Teperman, L & Nalesnik, M 2009, 'Donor-derived disease transmission events in the united states: Data reviewed by the OPTN/UNOS disease transmission advisory committee', American Journal of Transplantation, vol. 9, no. 8, pp. 1929-1935. https://doi.org/10.1111/j.1600-6143.2009.02700.x
Ison, M. G. ; Hager, J. ; Blumberg, E. ; Burdick, J. ; Carney, K. ; Cutler, J. ; Dimaio, J. M. ; Hasz, R. ; Kuehnert, M. J. ; Ortiz-Rios, E. ; Teperman, L. ; Nalesnik, M. / Donor-derived disease transmission events in the united states : Data reviewed by the OPTN/UNOS disease transmission advisory committee. In: American Journal of Transplantation. 2009 ; Vol. 9, No. 8. pp. 1929-1935.
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