Donor risk index predicts graft failure reliably but not post-transplant infections

Laura H. Rosenberger, Jacob R. Gillen, Tjasa Hranjec, Jayme B. Stokes, Kenneth L. Brayman, Sean C. Kumer, Timothy M. Schmitt, Robert G. Sawyer

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: The Donor Risk Index (DRI) is used to predict graft survival following liver transplantation, but has not been used to predict post-operative infections in graft recipients. We hypothesized that lower-quality grafts would result in more frequent infectious complications. Methods: Using a prospectively collected infection data set, we matched liver transplant recipients (and the respective allograft DRI scores) with their specific post-transplant infectious complications. All transplant recipients were organized by DRI score and divided into groups with low-DRI and high-DRI scores. Results: We identified 378 liver transplants, with 189 recipients each in the low-DRI and high-DRI groups. The mean DRI scores for the low- and high-DRI-score groups were 1.14±0.01 and 1.74±0.02, respectively (p<0.0001 for the difference). The mean Model for End-Stage Liver Disease (MELD) scores were 26.25±0.53 and 24.76±0.55, respectively (p=0.052), and the mean number of infectious complications per patient were 1.60±0.19 and 1.94±0.24, respectively (p=0.26). Logistic regression showed only length of hospital stay and a history of vascular disease as being associated independently with infection, with a trend toward significance for MELD score (p=0.13). Conclusion: We conclude that although DRI score predicts graft-liver survival, infectious complications depend more heavily on recipient factors.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalSurgical Infections
Volume15
Issue number2
DOIs
StatePublished - Apr 1 2014

ASJC Scopus subject areas

  • Surgery
  • Microbiology (medical)
  • Infectious Diseases

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    Rosenberger, L. H., Gillen, J. R., Hranjec, T., Stokes, J. B., Brayman, K. L., Kumer, S. C., Schmitt, T. M., & Sawyer, R. G. (2014). Donor risk index predicts graft failure reliably but not post-transplant infections. Surgical Infections, 15(2), 94-98. https://doi.org/10.1089/sur.2013.035