DOPA accumulates in the hypothalamic-hypophysial portal vessels and is taken into the anterior pituitary of NSD-1015-treated rodents

N. Telford, P. C. May, Y. N. Sinha, J. C. Porter, C. E. Finch

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

DOPA was measured in the anterior pituitary and hypothalamic-hypophysial portal blood after treatment with NSD-1015, a DOPA decarboxylase inhibitor. NSD-1015 caused DOPA to accumulate in the anterior pituitary of mice and rats, and increased DOPA in the hypothalamic-hypophysial portal blood of rat. Serum prolactin was also increased. Interruption of the anterior pituitary blood supply from the hypothalamic-hypophysial system by cannulation of the entire pituitary stalk eliminated the NSD-1015-induced DOPA accumulation in the rat pituitary. We conclude that DOPA can be taken into the anterior pituitary from the portal blood of NSD-1015-treated rodents and that the anterior pituitary lacks tyrosine hydroxylase activity in both mice and rats.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalNeuroendocrinology
Volume55
Issue number4
StatePublished - 1992

Fingerprint

Rodentia
Tyrosine 3-Monooxygenase
Pituitary Gland
Catheterization
Prolactin
3-hydroxybenzylhydrazine
Serum
Therapeutics

Keywords

  • Anterior pituitary
  • DOPA
  • Dopamine
  • Portal blood
  • Prolactin
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

DOPA accumulates in the hypothalamic-hypophysial portal vessels and is taken into the anterior pituitary of NSD-1015-treated rodents. / Telford, N.; May, P. C.; Sinha, Y. N.; Porter, J. C.; Finch, C. E.

In: Neuroendocrinology, Vol. 55, No. 4, 1992, p. 390-395.

Research output: Contribution to journalArticle

Telford, N. ; May, P. C. ; Sinha, Y. N. ; Porter, J. C. ; Finch, C. E. / DOPA accumulates in the hypothalamic-hypophysial portal vessels and is taken into the anterior pituitary of NSD-1015-treated rodents. In: Neuroendocrinology. 1992 ; Vol. 55, No. 4. pp. 390-395.
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AU - Sinha, Y. N.

AU - Porter, J. C.

AU - Finch, C. E.

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AB - DOPA was measured in the anterior pituitary and hypothalamic-hypophysial portal blood after treatment with NSD-1015, a DOPA decarboxylase inhibitor. NSD-1015 caused DOPA to accumulate in the anterior pituitary of mice and rats, and increased DOPA in the hypothalamic-hypophysial portal blood of rat. Serum prolactin was also increased. Interruption of the anterior pituitary blood supply from the hypothalamic-hypophysial system by cannulation of the entire pituitary stalk eliminated the NSD-1015-induced DOPA accumulation in the rat pituitary. We conclude that DOPA can be taken into the anterior pituitary from the portal blood of NSD-1015-treated rodents and that the anterior pituitary lacks tyrosine hydroxylase activity in both mice and rats.

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