DOPA accumulates in the hypothalamic-hypophysial portal vessels and is taken into the anterior pituitary of NSD-1015-treated rodents

N. Telford, P. C. May, Y. N. Sinha, J. C. Porter, C. E. Finch

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

DOPA was measured in the anterior pituitary and hypothalamic-hypophysial portal blood after treatment with NSD-1015, a DOPA decarboxylase inhibitor. NSD-1015 caused DOPA to accumulate in the anterior pituitary of mice and rats, and increased DOPA in the hypothalamic-hypophysial portal blood of rat. Serum prolactin was also increased. Interruption of the anterior pituitary blood supply from the hypothalamic-hypophysial system by cannulation of the entire pituitary stalk eliminated the NSD-1015-induced DOPA accumulation in the rat pituitary. We conclude that DOPA can be taken into the anterior pituitary from the portal blood of NSD-1015-treated rodents and that the anterior pituitary lacks tyrosine hydroxylase activity in both mice and rats.

Original languageEnglish (US)
Pages (from-to)390-395
Number of pages6
JournalNeuroendocrinology
Volume55
Issue number4
DOIs
StatePublished - Jan 1 1992

Keywords

  • Anterior pituitary
  • DOPA
  • Dopamine
  • Portal blood
  • Prolactin
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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