DOPA AS AN ANTIMETABOLITE IN HUNTINGTON'S DISEASE

Fred Baskin, RogerN Rosenberg

Research output: Contribution to journalArticle

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Abstract

A point mutation affecting the primary structure of an enzyme which usually distinguishes between dopa or a dopa metabolite and tyrosine could explain the neuronal cell death which is characteristic of Huntington's disease. The dopa metabolite would then act as an antimetabolite, inhibiting the tyrosine t-R.N.A. acylation step, blocking protein synthesis, and eventually causing cell death.

Original languageEnglish (US)
Pages (from-to)582-583
Number of pages2
JournalThe Lancet
Volume301
Issue number7803
DOIs
StatePublished - Mar 17 1973

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ASJC Scopus subject areas

  • Medicine(all)

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