Dopamine D1 binding potential predicts fusiform BOLD activity during face-recognition performance

Bart Rypma, Håkan Fischer, Anna Rieckmann, Nicholas A. Hubbard, Lars Nyberg, Lars Bäckman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The importance of face memory in humans and primates is well established, but little is known about the neurotransmitter systems involved in face recognition. We tested the hypothesis that face recognition is linked to dopamine (DA) activity in fusiform gyrus (FFG). DA availability was assessed by measuring D1 binding potential (BP) during rest using PET. We further assessed blood-oxygen-leveldependent (BOLD) signal change while subjects performed a face-recognition task during fMRI scanning. There was a strong association betweenD1BPandBOLDactivity in FFG, whereasD1BPin striatal and other extrastriatal regions were unrelated to neural activity in FFG. These results suggest that D1 BP locally modulates FFG function during face recognition. Observed relationships among D1 BP, BOLD activity, and face-recognition performance further suggest that D1 receptors place constraints on the responsiveness of FFG neurons.

Original languageEnglish (US)
Pages (from-to)14702-14707
Number of pages6
JournalJournal of Neuroscience
Volume35
Issue number44
DOIs
StatePublished - Nov 4 2015

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Temporal Lobe
Dopamine
Oxygen
Corpus Striatum
Primates
Neurotransmitter Agents
Magnetic Resonance Imaging
Facial Recognition
Neurons

Keywords

  • Dopamine
  • Face recognition
  • FMRI
  • Fusiform gyrus
  • Multimodal imaging
  • PET

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dopamine D1 binding potential predicts fusiform BOLD activity during face-recognition performance. / Rypma, Bart; Fischer, Håkan; Rieckmann, Anna; Hubbard, Nicholas A.; Nyberg, Lars; Bäckman, Lars.

In: Journal of Neuroscience, Vol. 35, No. 44, 04.11.2015, p. 14702-14707.

Research output: Contribution to journalArticle

Rypma, Bart ; Fischer, Håkan ; Rieckmann, Anna ; Hubbard, Nicholas A. ; Nyberg, Lars ; Bäckman, Lars. / Dopamine D1 binding potential predicts fusiform BOLD activity during face-recognition performance. In: Journal of Neuroscience. 2015 ; Vol. 35, No. 44. pp. 14702-14707.
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