Dopamine efflux in response to ultraviolet radiation in addicted sunbed users

Pamela M. Aubert, John P. Seibyl, Julianne L. Price, Thomas S. Harris, Francesca M. Filbey, Heidi Jacobe, Michael D. Devous, Bryon Adinoff

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Compulsive tanning despite awareness of ultraviolet radiation (UVR) carcinogenicity may represent an "addictive" behavior. Many addictive disorders are associated with alterations in dopamine (D2/D3) receptor binding and dopamine reactivity in the brain's reward pathway. To determine if compulsive tanners exhibited neurobiologic responses similar to other addictive disorders, this study assessed basal striatal D2/D3 binding and UVR-induced striatal dopamine efflux in ten addicted and ten infrequent tanners. In a double-blind crossover trial, UVR or sham UVR was administered in separate sessions during brain imaging with single photon emission computerized tomography (SPECT). Basal D2/D3 receptor density and UVR-induced dopamine efflux in the caudate were assessed using 123I-iodobenzamide (123I-IBZM) binding potential non-displaceable (BPnd). Basal BPnd did not significantly differ between addicted and infrequent tanners. Whereas neither UVR nor sham UVR induced significant changes in bilateral caudate BPnd in either group, post-hoc analyses revealed left caudate BPnd significantly decreased (reflecting increased dopamine efflux) in the addicted tanners - but not the infrequent tanners - during the UVR session only. Bilateral δBPnd correlated with tanning severity only in the addicted tanners. These preliminary findings are consistent with a stronger neural rewarding response to UVR in addicted tanners, supporting a cutaneous-neural connection driving excessive sunbed use.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume251
DOIs
StatePublished - May 30 2016

Fingerprint

Dopamine
Radiation
Tanning
Corpus Striatum
Dopamine D3 Receptors
Addictive Behavior
Dopamine D2 Receptors
Single-Photon Emission-Computed Tomography
Reward
Neuroimaging
Cross-Over Studies
Skin
Brain

Keywords

  • Addiction
  • Dopamine
  • Imaging
  • Mesostriatal reward system
  • SPECT
  • Tanning

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Dopamine efflux in response to ultraviolet radiation in addicted sunbed users. / Aubert, Pamela M.; Seibyl, John P.; Price, Julianne L.; Harris, Thomas S.; Filbey, Francesca M.; Jacobe, Heidi; Devous, Michael D.; Adinoff, Bryon.

In: Psychiatry Research - Neuroimaging, Vol. 251, 30.05.2016, p. 7-14.

Research output: Contribution to journalArticle

Aubert, PM, Seibyl, JP, Price, JL, Harris, TS, Filbey, FM, Jacobe, H, Devous, MD & Adinoff, B 2016, 'Dopamine efflux in response to ultraviolet radiation in addicted sunbed users', Psychiatry Research - Neuroimaging, vol. 251, pp. 7-14. https://doi.org/10.1016/j.pscychresns.2016.04.001
Aubert, Pamela M. ; Seibyl, John P. ; Price, Julianne L. ; Harris, Thomas S. ; Filbey, Francesca M. ; Jacobe, Heidi ; Devous, Michael D. ; Adinoff, Bryon. / Dopamine efflux in response to ultraviolet radiation in addicted sunbed users. In: Psychiatry Research - Neuroimaging. 2016 ; Vol. 251. pp. 7-14.
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