Dopamine in hypophysial portal plasma and prolactin in systemic plasma of rats treated with 5-hydroxytryptamine

N. S. Pilotte, J. C. Porter

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Abstract

Intracerebroventricularly administered 5-hydroxytryptamine (5HT) altered the release of dopamine into pituitary stalk blood and of PRL into the systemic circulation of male rats. The concentration of dopamine in pituitary stalk plasma of rats given 0.5 or 5.0 μg 5HT was 0.32 ± 0.06 (mean ± SE) or 0.18 ± 0.04 ng/ml, respectively, and was significantly less than that in vehicle-treated animals (0.80 ±0.04 ng/ml). Relative to the mean level of PRL in animals injected with the solvent vehicle, the mean concentration of PRL in central venous plasma of rats given 0.5 or 5.0 μg 5HT was increased 4-fold or 13-fold respectively. Other rats were infused iv with dopamine for 45 min. After 15 min of infusion, the mean concentration of dopamine in arterial plasma was several times that of dopamine in pituitary stalk plasma of rats not infused with dopamine. Even so, this high concentration of dopamine did not prevent the 5HT-induced release of PRL. We conclude that 5HT modulates the secretion of PRL through a stimulatory mechanism that is effective in the presence of a high plasma concentration of dopamine, a PRL-release inhibiting factor, and suggest that 5HT causes the release of a hypothalamic substance(s) that stimulates release of PRL, i.e. a PRL-releasing factor.

Original languageEnglish (US)
Pages (from-to)2137-2141
Number of pages5
JournalEndocrinology
Volume108
Issue number6
StatePublished - 1981

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Prolactin
Dopamine
Serotonin
Pituitary Gland

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Dopamine in hypophysial portal plasma and prolactin in systemic plasma of rats treated with 5-hydroxytryptamine. / Pilotte, N. S.; Porter, J. C.

In: Endocrinology, Vol. 108, No. 6, 1981, p. 2137-2141.

Research output: Contribution to journalArticle

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