Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

William Menegas, Joseph F. Bergan, Sachie K. Ogawa, Yoh Isogai, Kannan Umadevi Venkataraju, Pavel Osten, Naoshige Uchida, Mitsuko Watabe-Uchida

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, cortex, amygdala, etc) in mice. We found that most populations of dopamine neurons receive a similar set of inputs rather than forming strong reciprocal connections with their target areas. A common feature among most populations of dopamine neurons was the existence of dense ‘clusters’ of inputs within the ventral striatum. However, we found that dopamine neurons projecting to the posterior striatum were outliers, receiving relatively few inputs from the ventral striatum and instead receiving more inputs from the globus pallidus, subthalamic nucleus, and zona incerta. These results lay a foundation for understanding the input/output structure of the midbrain dopamine circuit and demonstrate that dopamine neurons projecting to the posterior striatum constitute a unique class of dopamine neurons regulated by different inputs.

Original languageEnglish (US)
Article numbere10032
JournaleLife
Volume4
Issue numberAUGUST2015
DOIs
StatePublished - Aug 31 2015

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Dopaminergic Neurons
Neurons
Dopamine
Mesencephalon
Rabies virus
Subthalamic Nucleus
Globus Pallidus
Amygdala
Population
Viruses
Brain
Light
Imaging techniques
Networks (circuits)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Menegas, W., Bergan, J. F., Ogawa, S. K., Isogai, Y., Venkataraju, K. U., Osten, P., ... Watabe-Uchida, M. (2015). Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. eLife, 4(AUGUST2015), [e10032]. https://doi.org/10.7554/eLife.10032

Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. / Menegas, William; Bergan, Joseph F.; Ogawa, Sachie K.; Isogai, Yoh; Venkataraju, Kannan Umadevi; Osten, Pavel; Uchida, Naoshige; Watabe-Uchida, Mitsuko.

In: eLife, Vol. 4, No. AUGUST2015, e10032, 31.08.2015.

Research output: Contribution to journalArticle

Menegas, W, Bergan, JF, Ogawa, SK, Isogai, Y, Venkataraju, KU, Osten, P, Uchida, N & Watabe-Uchida, M 2015, 'Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass', eLife, vol. 4, no. AUGUST2015, e10032. https://doi.org/10.7554/eLife.10032
Menegas W, Bergan JF, Ogawa SK, Isogai Y, Venkataraju KU, Osten P et al. Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. eLife. 2015 Aug 31;4(AUGUST2015). e10032. https://doi.org/10.7554/eLife.10032
Menegas, William ; Bergan, Joseph F. ; Ogawa, Sachie K. ; Isogai, Yoh ; Venkataraju, Kannan Umadevi ; Osten, Pavel ; Uchida, Naoshige ; Watabe-Uchida, Mitsuko. / Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. In: eLife. 2015 ; Vol. 4, No. AUGUST2015.
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