Dopamine receptor regulating factor, DRRF

A zinc finger transcription factor

Cheol Kyu Hwang, Ursula M. D'Souza, Amelia J. Eisch, Shunsuke Yajima, Claas Hinrich Lammers, Young Yang, Sang Hyeon Lee, Yong Man Kim, Eric J. Nestler, M. Maral Mouradian

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger type transcription factor, designated dopamine receptor regulating factor (DRRF), which binds to GC and GT boxes in the D1A and D2 dopamine receptor promoters and effectively displaces Sp1 and Sp3 from these sequences. Consequently, DRRF can modulate the activity of these dopamine receptor promoters. Highest DRRF mRNA levels are found in brain with a specific regional distribution including olfactory bulb and tubercle, nucleus accumbens, striatum, hippocampus, amygdala, and frontal cortex. Many of these brain regions also express abundant levels of various dopamine receptors. In vivo, DRRF itself can be regulated by manipulations of dopaminergic transmission. Mice treated with drugs that increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) show significant alterations in DRRF mRNA. The latter observations provide a basis for dopamine receptor regulation after these manipulations. We conclude that DRRF is important for modulating dopaminergic transmission in the brain.

Original languageEnglish (US)
Pages (from-to)7558-7563
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number13
DOIs
StatePublished - Jun 19 2001

Fingerprint

Zinc Fingers
Dopamine Receptors
Transcription Factors
Brain
Dopamine
Corpus Striatum
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Messenger RNA
Dopamine D2 Receptors
Olfactory Bulb
Nucleus Accumbens
Frontal Lobe
Haloperidol
Amygdala
Cocaine
Hippocampus

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Dopamine receptor regulating factor, DRRF : A zinc finger transcription factor. / Hwang, Cheol Kyu; D'Souza, Ursula M.; Eisch, Amelia J.; Yajima, Shunsuke; Lammers, Claas Hinrich; Yang, Young; Lee, Sang Hyeon; Kim, Yong Man; Nestler, Eric J.; Mouradian, M. Maral.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 13, 19.06.2001, p. 7558-7563.

Research output: Contribution to journalArticle

Hwang, CK, D'Souza, UM, Eisch, AJ, Yajima, S, Lammers, CH, Yang, Y, Lee, SH, Kim, YM, Nestler, EJ & Mouradian, MM 2001, 'Dopamine receptor regulating factor, DRRF: A zinc finger transcription factor', Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 13, pp. 7558-7563. https://doi.org/10.1073/pnas.121635798
Hwang, Cheol Kyu ; D'Souza, Ursula M. ; Eisch, Amelia J. ; Yajima, Shunsuke ; Lammers, Claas Hinrich ; Yang, Young ; Lee, Sang Hyeon ; Kim, Yong Man ; Nestler, Eric J. ; Mouradian, M. Maral. / Dopamine receptor regulating factor, DRRF : A zinc finger transcription factor. In: Proceedings of the National Academy of Sciences of the United States of America. 2001 ; Vol. 98, No. 13. pp. 7558-7563.
@article{ca027c01272d4100af86237315d801a7,
title = "Dopamine receptor regulating factor, DRRF: A zinc finger transcription factor",
abstract = "Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger type transcription factor, designated dopamine receptor regulating factor (DRRF), which binds to GC and GT boxes in the D1A and D2 dopamine receptor promoters and effectively displaces Sp1 and Sp3 from these sequences. Consequently, DRRF can modulate the activity of these dopamine receptor promoters. Highest DRRF mRNA levels are found in brain with a specific regional distribution including olfactory bulb and tubercle, nucleus accumbens, striatum, hippocampus, amygdala, and frontal cortex. Many of these brain regions also express abundant levels of various dopamine receptors. In vivo, DRRF itself can be regulated by manipulations of dopaminergic transmission. Mice treated with drugs that increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) show significant alterations in DRRF mRNA. The latter observations provide a basis for dopamine receptor regulation after these manipulations. We conclude that DRRF is important for modulating dopaminergic transmission in the brain.",
author = "Hwang, {Cheol Kyu} and D'Souza, {Ursula M.} and Eisch, {Amelia J.} and Shunsuke Yajima and Lammers, {Claas Hinrich} and Young Yang and Lee, {Sang Hyeon} and Kim, {Yong Man} and Nestler, {Eric J.} and Mouradian, {M. Maral}",
year = "2001",
month = "6",
day = "19",
doi = "10.1073/pnas.121635798",
language = "English (US)",
volume = "98",
pages = "7558--7563",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "13",

}

TY - JOUR

T1 - Dopamine receptor regulating factor, DRRF

T2 - A zinc finger transcription factor

AU - Hwang, Cheol Kyu

AU - D'Souza, Ursula M.

AU - Eisch, Amelia J.

AU - Yajima, Shunsuke

AU - Lammers, Claas Hinrich

AU - Yang, Young

AU - Lee, Sang Hyeon

AU - Kim, Yong Man

AU - Nestler, Eric J.

AU - Mouradian, M. Maral

PY - 2001/6/19

Y1 - 2001/6/19

N2 - Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger type transcription factor, designated dopamine receptor regulating factor (DRRF), which binds to GC and GT boxes in the D1A and D2 dopamine receptor promoters and effectively displaces Sp1 and Sp3 from these sequences. Consequently, DRRF can modulate the activity of these dopamine receptor promoters. Highest DRRF mRNA levels are found in brain with a specific regional distribution including olfactory bulb and tubercle, nucleus accumbens, striatum, hippocampus, amygdala, and frontal cortex. Many of these brain regions also express abundant levels of various dopamine receptors. In vivo, DRRF itself can be regulated by manipulations of dopaminergic transmission. Mice treated with drugs that increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) show significant alterations in DRRF mRNA. The latter observations provide a basis for dopamine receptor regulation after these manipulations. We conclude that DRRF is important for modulating dopaminergic transmission in the brain.

AB - Dopamine receptor genes are under complex transcription control, determining their unique regional distribution in the brain. We describe here a zinc finger type transcription factor, designated dopamine receptor regulating factor (DRRF), which binds to GC and GT boxes in the D1A and D2 dopamine receptor promoters and effectively displaces Sp1 and Sp3 from these sequences. Consequently, DRRF can modulate the activity of these dopamine receptor promoters. Highest DRRF mRNA levels are found in brain with a specific regional distribution including olfactory bulb and tubercle, nucleus accumbens, striatum, hippocampus, amygdala, and frontal cortex. Many of these brain regions also express abundant levels of various dopamine receptors. In vivo, DRRF itself can be regulated by manipulations of dopaminergic transmission. Mice treated with drugs that increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) show significant alterations in DRRF mRNA. The latter observations provide a basis for dopamine receptor regulation after these manipulations. We conclude that DRRF is important for modulating dopaminergic transmission in the brain.

UR - http://www.scopus.com/inward/record.url?scp=0035912734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035912734&partnerID=8YFLogxK

U2 - 10.1073/pnas.121635798

DO - 10.1073/pnas.121635798

M3 - Article

VL - 98

SP - 7558

EP - 7563

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 13

ER -