Dopamine transporter SPECT imaging in parkinson disease and dementia

Devaki Shilpa Surasi, Patrick J. Peller, Zsolt Szabo, Gustavo Mercier, Rathan Subramaniam

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The diagnosis of Parkinson disease (PD) and dementia with Lewy bodies (DLB) is often not straightforward. When PD symptoms are atypical or overlap with other diseases (eg, essential tremor [ET] or drug induced), [123I] N-ω-fluoropropyl-2β-carbomethoxy-3b-(4-iodophenyl) nortropane ([ 123I]FP-CIT) single-photon emission computed tomography (SPECT) can improve the diagnostic accuracy. The potential side effects of medications for PD may be avoided, if [123I]FP-CIT SPECT is normal. [ 123I]FP-CIT SPECT is helpful in the diagnosis of DLB, differentiating it from other causes of dementia such as Alzheimer disease (AD).

Original languageEnglish (US)
Pages (from-to)459-467
Number of pages9
JournalPET Clinics
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2013

Fingerprint

Parkinson disease
transporter
dopamine
Dopamine Plasma Membrane Transport Proteins
Single-Photon Emission-Computed Tomography
Parkinson Disease
Dementia
Lewy Body Disease
tomography
Nortropanes
photons
Essential Drugs
Essential Tremor
tremors
Alzheimer Disease
drugs
causes
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane

Keywords

  • Dementia
  • Dopamine
  • Parkinson disease
  • SPECT

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Dopamine transporter SPECT imaging in parkinson disease and dementia. / Surasi, Devaki Shilpa; Peller, Patrick J.; Szabo, Zsolt; Mercier, Gustavo; Subramaniam, Rathan.

In: PET Clinics, Vol. 8, No. 4, 01.01.2013, p. 459-467.

Research output: Contribution to journalArticle

Surasi, Devaki Shilpa ; Peller, Patrick J. ; Szabo, Zsolt ; Mercier, Gustavo ; Subramaniam, Rathan. / Dopamine transporter SPECT imaging in parkinson disease and dementia. In: PET Clinics. 2013 ; Vol. 8, No. 4. pp. 459-467.
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